Setembro 2013 vol. 1 num. 1 - Brazilian Meeting on Organic Synthesis 2011

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A simple approach to symmetrical and unsymmetrical ureas

Viana, G. M. ; Ferrão, J. A. ; Senra, J. D. ; Vasconcelos, M. G. ; Simas, A. B. C. ; Aguiar, L. C. S. ;

Abstract:

Mild and efficient methods for the synthesis of substituted ureas have continued to attract a widespread interest for a long time due to their diverse biological activity. Here we wish to report a new facile methodology to prepare substituted ureas, just treating their respective thioureas with aqueous potassium dichloroiodate (KICl2). An interesting oxidation reaction in organic chemistry is the oxidation of thioureas. Depending on the oxidizing agent, reaction conditions and the substitution pattern of thioureas, a variety of products have been isolated. Different from the literature reports dealing with methodologies describing that thioureas can be transformed into ureas (lead tetraacetate; oxone; manganese dioxide; tetrabutylammonium perio-date), our approach also allows the simultaneous synthesis of iodinated aryl-ureas.

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Palavras-chave: urea, thiourea, potassium dichloroiodate,

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DOI: 10.5151/chempro-14bmos-R0338-1

Referências bibliográficas
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Como citar:

Viana, G. M.; Ferrão, J. A.; Senra, J. D.; Vasconcelos, M. G.; Simas, A. B. C.; Aguiar, L. C. S.; "A simple approach to symmetrical and unsymmetrical ureas", p. 338 . In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 1, Setembro.2013. São Paulo: Blucher, 2013.
ISSN 2318-4043, DOI 10.5151/chempro-14bmos-R0338-1

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