Dezembro 2013 vol. 1 num. 2 - Brazilian Meeting on Organic Synthesis 2013

Abstract - Open Access.

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A three step continuous flow synthesis of the biaryl unit of the HIV protease inhibitor Atazanavir.

Vechia, Luciana Dalla ; Reichart, Benedikt ; Glasnov, Toma ; Miranda, Leandro S. M. ; Kappe, C. Oliver ; Souza, Rodrigo O. M. A. de ;

Abstract:

Continuous flow technology has attracted the attention of the organic chemistry community in the last decade, both as an enabling tool to enhance organic synthesis and as a manufacturing method. The continuous flow synthesis of active pharmaceutical ingredients (APIs), which typically involve a significant number of synthetic steps, therefore clearly is a rather complex operation. Atazanavir is one of the most prescribed protease inhibitors in Brazil (and worldwide) and thus a sufficient and cost effective supply to Atazanavir is of prime importance. The retrosynthetic analysis for the Atazanavir (1) molecule is shown in Figure 1 and reveals an assembly three different building blocks.

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Palavras-chave: continuous flow, atazanavir, biaryl,

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DOI: 10.5151/chempro-15bmos-BMOS2013_2013917165936

Referências bibliográficas
  • [1] 1 Noël, T.; Buchwald, S. L. Chem. Soc. Rev. 2011, 5010.
  • [2] 2 Xu, Z. et al. Org. Process Res. Dev. 2002, 323.
Como citar:

Vechia, Luciana Dalla; Reichart, Benedikt; Glasnov, Toma; Miranda, Leandro S. M.; Kappe, C. Oliver; Souza, Rodrigo O. M. A. de; "A three step continuous flow synthesis of the biaryl unit of the HIV protease inhibitor Atazanavir.", p. 286 . In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 2, Dezembro.2013. São Paulo: Blucher, 2013.
ISSN 2318-4043, DOI 10.5151/chempro-15bmos-BMOS2013_2013917165936

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