Advanced Methods of Biofunctionalization of Metallic, Polymer and Deimmunized Donor’s Bone Biomaterials

Advanced Methods of Biofunctionalization of Metallic, Polymer and Deimmunized Donor’s Bone Biomaterials

Shtansky, Dmitry V.; Batenina, Irina V.; Levashov, Evgeny A.; Sheveiko, Alexander N.; Gloushankova, Natalia A.; Anisimova, Natalia Y.; Kiselevski, Mikhail V.; Grigoryan, Alexei S.; Reshetov, Igor V.

Abstract:

Surface engineering is an effective tool to modify chemical, mechanical, and biological characteristics of various material surfaces, while retaining their bulk properties. The possibility to produce biocompatible materials with controllable topography and roughness, blind porosity, and desired chemical composition opens new avenues for the design of novel hybrid implants [1]. The present paper focuses on the surface modification of three different types of materials (metals, polytetrafluoroethylene (PTFE), and deimmunized donor’s bone) using various advanced techniques such as sandblast treatment, cold spray, selective laser sintering, pulsed electro-erosion treatment, ion etching, ion implantation, and magnetron sputtering to control surface roughness, blind porosity, surface chemistry, and wettability, i.e. the characteristics which affect osseointegration. To change the surface chemistry, the samples were covered by multicomponent biocompatible nanostructured films (MuBiNaFs) [2]. An excellent combination of chemical, mechanical, and biological properties makes such MuBiNaFs very attractive materials for bioengineering and modification of various implant surfaces. A key MuBiNaFs property that can be improved further is their antibacterial effect, which is achieved without compromising the material bioactivity and biocompatibility [3]. Another promising application is the fabrication of hybrid materials incorporated with stem cells or medicine [2,4].

Surface engineering is an effective tool to modify chemical, mechanical, and biological characteristics of various material surfaces, while retaining their bulk properties. The possibility to produce biocompatible materials with controllable topography and roughness, blind porosity, and desired chemical composition opens new avenues for the design of novel hybrid implants [1]. The present paper focuses on the surface modification of three different types of materials (metals, polytetrafluoroethylene (PTFE), and deimmunized donor’s bone) using various advanced techniques such as sandblast treatment, cold spray, selective laser sintering, pulsed electro-erosion treatment, ion etching, ion implantation, and magnetron sputtering to control surface roughness, blind porosity, surface chemistry, and wettability, i.e. the characteristics which affect osseointegration. To change the surface chemistry, the samples were covered by multicomponent biocompatible nanostructured films (MuBiNaFs) [2]. An excellent combination of chemical, mechanical, and biological properties makes such MuBiNaFs very attractive materials for bioengineering and modification of various implant surfaces. A key MuBiNaFs property that can be improved further is their antibacterial effect, which is achieved without compromising the material bioactivity and biocompatibility [3]. Another promising application is the fabrication of hybrid materials incorporated with stem cells or medicine [2,4].

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Shtansky, Dmitry V.; Batenina, Irina V.; Levashov, Evgeny A.; Sheveiko, Alexander N.; Gloushankova, Natalia A.; Anisimova, Natalia Y.; Kiselevski, Mikhail V.; Grigoryan, Alexei S.; Reshetov, Igor V.; "Advanced Methods of Biofunctionalization of Metallic, Polymer and Deimmunized Donor’s Bone Biomaterials", p-2-2. In: Proceedings of the 13th International Symposium on Multiscale, Multifunctional and Functionally Graded Materials [=Blucher Material Science Proceedings, v.1, n.1]. São Paulo: Blucher, 2014.
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