Setembro 2013 vol. 1 num. 1 - Brazilian Meeting on Organic Synthesis 2011

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AN APPROACH TO THE SYNTHESIS OF SUBSTITUTED CYCLOPENTENONES WITH POTENTIAL ANTI-INFLAMMATORY ACTIVITY FROM MORITA-BAYLIS-HILLMAN ADDUCT

Filho, Luis Gustavo de Sousa ; Coelho, Fernando ;

Abstract:

The cyclopentenone prostanoids are derived prostaglandin D2, the latter being a byproduct of the metabolism of arachidonic acid in inflammation. The cyclopentenone core play several biological activities, namely: anti-inflammatory, anticancer and antiviral. Due to the biological importance of this structural motif, we began a research project aimed at synthesizing some potentially anti-inflammatory cyclopentenone derivatives using a Morita-Baylis- Hillman adduct as substrate. So, we described herein a new approach for the construction of substituted cyclopentenone derivatives. These cyclopentenones present in their structures some requirements to deliver anti-inflammatory activity.

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Palavras-chave: Morita-Baylis-Hillman, rhodium-catalyzed 1, 4-addition, cyclopentenones,

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DOI: 10.5151/chempro-14bmos-R0255-1

Referências bibliográficas
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  • [3] 3 Coelho, F.; Almeida, W. P.; Veronese, D.; Mateus, C. R.; Lopes, E. C. S.; Rossi, R. C.; Silveira, G. P. C.; Pavam, C. H. Tetrahedron 2002, 58, 7437.
  • [4] 4 Navarre, L.; Darses, S.; Genet, J.-P. Chem.Commun. 2004, 1108.
Como citar:

Filho, Luis Gustavo de Sousa; Coelho, Fernando; "AN APPROACH TO THE SYNTHESIS OF SUBSTITUTED CYCLOPENTENONES WITH POTENTIAL ANTI-INFLAMMATORY ACTIVITY FROM MORITA-BAYLIS-HILLMAN ADDUCT", p. 255 . In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 1, Setembro.2013. São Paulo: Blucher, 2013.
ISSN 2318-4043, DOI 10.5151/chempro-14bmos-R0255-1

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