Anti-Helicobacter pylori Activity of New Synthetic Fenitoin Derivatives

Anti-Helicobacter pylori Activity of New Synthetic Fenitoin Derivatives

Aspesi, Geisa Helmold; Arruda, Ana Lúcia Alves de; Andrade, Carlos Kleber Z.

Abstract:

Many hidantoin derivatives have pharmacological activities (anticonvulsant, antifungic, antibacterial and antiparasitic), related to the substituent in positions 3 or 5 of the imidazolidinic-like ring. In this work, several 3-substituted imidazolidinic-like compounds were synthesized from fenitoin, aiming at potential new drugs presenting more selectivity, security, less toxicity and lower cost on the treatment of ulcer, caused by Helicobacter pylori.

Many hidantoin derivatives have pharmacological activities (anticonvulsant, antifungic, antibacterial and antiparasitic), related to the substituent in positions 3 or 5 of the imidazolidinic-like ring. In this work, several 3-substituted imidazolidinic-like compounds were synthesized from fenitoin, aiming at potential new drugs presenting more selectivity, security, less toxicity and lower cost on the treatment of ulcer, caused by Helicobacter pylori.

Palavras-chave:

DOI: 10.5151/chempro-14bmos-R0202-1

Referências bibliográficas

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Como citar:

Aspesi, Geisa Helmold; Arruda, Ana Lúcia Alves de; Andrade, Carlos Kleber Z.; "Anti-Helicobacter pylori Activity of New Synthetic Fenitoin Derivatives", p-202-202. In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 1, Setembro.2013. São Paulo: Blucher, 2013.
ISSN 23184043, DOI 10.5151/chempro-14bmos-R0202-1