Asymmetrical Henry reaction using copper (II)/2-oxazoline complex.

Asymmetrical Henry reaction using copper (II)/2-oxazoline complex.

Mello, Murilo B. M.; Oliveira, Alfredo R. M.; Ribeiro, and Ronny R.

Abstract:

The Henry reaction or nitro aldol reaction is one of the most versatile methods to obtain a new C-C bond. The asymmetric version of this reaction has been used to generate a variety of useful building blocks for organic synthesis. The catalytic asymmetric Henry reaction uses chiral ligands as a source of asymmetry and amino alcohols have found applications as catalysts in asymmetric reactions. Among several asymmetric ligands, several 2-oxazolines derivatives have been used as metal ligands in this type of reaction. In this context, the asymmetrical catalyst copper/2- oxazoline chiral derivative was studied using a new class of chiral 2-oxazoline compounds.

The Henry reaction or nitro aldol reaction is one of the most versatile methods to obtain a new C-C bond. The asymmetric version of this reaction has been used to generate a variety of useful building blocks for organic synthesis. The catalytic asymmetric Henry reaction uses chiral ligands as a source of asymmetry and amino alcohols have found applications as catalysts in asymmetric reactions. Among several asymmetric ligands, several 2-oxazolines derivatives have been used as metal ligands in this type of reaction. In this context, the asymmetrical catalyst copper/2- oxazoline chiral derivative was studied using a new class of chiral 2-oxazoline compounds.

Palavras-chave:

DOI: 10.5151/chempro-15bmos-BMOS2013_201391314107

Referências bibliográficas

• [1] Yuan, H., Hu, J., Gong, Y., Tetrahedron: Asymmetry, 2013, 24, 699.
• [2] Ebru Aydin, A., Applied Organometallic Chemistry, 2013, 27, 283.
• [3] Zhou, Z.-M., Li, Z.-H., Hao, X.-Y., Zhang, J., Dong, X., Liu, Y.-Q., Sun, W.-W., Cao, D., Wang, J.-L., Organic And Biomolecular Chemistry, 2012, 10, 2113.
• [4] Evans, D. A., Seidel, D., Rueping, M., Lan, H. W., Shaw, J. T., Downey, C. W., Journal of the American Chemical Society, 2003, 125, 12692.
• [5] Didier, D., Schulz, E., Tetrahedron: Asymmetry, 2013, 24, 769.
• [6] Peisach, J.; Blumberg, W.E. Arch. Biochem. Biophys. 1974 165(2), 691.
• [7] Batók, M., Chemical Reviews, 2009, 110, 1663.

Como citar:

Mello, Murilo B. M.; Oliveira, Alfredo R. M.; Ribeiro, and Ronny R.; "Asymmetrical Henry reaction using copper (II)/2-oxazoline complex.", p-72-72. In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 2, Dezembro.2013. São Paulo: Blucher, 2013.
ISSN 23184043, DOI 10.5151/chempro-15bmos-BMOS2013_201391314107