Aza-bicycles Synthesis Through Formal Aza [3+3], [3+2+1] and [3+1+1+1] Cycloadditions Between Enaminones, Aldehydes and Meldrum’s Acid Derivatives.

Aza-bicycles Synthesis Through Formal Aza [3+3], [3+2+1] and [3+1+1+1] Cycloadditions Between Enaminones, Aldehydes and Meldrum’s Acid Derivatives.

Santana, Lourenço Luis Botelho de; Cunha, Silvio

Abstract:

Aza-bicycles are an important scafold because a great number of biological active alkaloids and synthetic analogous belong to this class. Employing enaminones in order to obtain these compounds is strategic, once enaminones are obtained in good yields and can be used to prepare diverse heterocycles. This work evaluates the bicomponent aza-annulation [3+3] reaction between enaminones and Meldrum’s acid derivatives, as well as the trimolecular [3+2+1] and the tetramolecular [3+1+1+1] multicomponent reactions.

Aza-bicycles are an important scafold because a great number of biological active alkaloids and synthetic analogous belong to this class. Employing enaminones in order to obtain these compounds is strategic, once enaminones are obtained in good yields and can be used to prepare diverse heterocycles. This work evaluates the bicomponent aza-annulation [3+3] reaction between enaminones and Meldrum’s acid derivatives, as well as the trimolecular [3+2+1] and the tetramolecular [3+1+1+1] multicomponent reactions.

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DOI: 10.5151/chempro-14bmos-R0056-1

Referências bibliográficas

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Como citar:

Santana, Lourenço Luis Botelho de; Cunha, Silvio; "Aza-bicycles Synthesis Through Formal Aza [3+3], [3+2+1] and [3+1+1+1] Cycloadditions Between Enaminones, Aldehydes and Meldrum’s Acid Derivatives.", p-56-56. In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 1, Setembro.2013. São Paulo: Blucher, 2013.
ISSN 23184043, DOI 10.5151/chempro-14bmos-R0056-1