Setembro 2013 vol. 1 num. 1 - Brazilian Meeting on Organic Synthesis 2011

Abstract - Open Access.

Idioma principal

Chemical synthesis of glycopeptide related to T. cruzi and cancer mucins

Campo, Vanessa Leiria ; Carvalho, Ivone ; Baruffi, Marcelo Dias ;

Abstract:

Mucins are highly O-glycosylated (about 60% carbohydrate by weight), glycoproteins that are rich in serine (Ser) and threonine (Thr) repeating units, whose external oligosaccharides are linked to the protein via sugar units of _-N-acetyl-glucosamine (GlcNAc), in T. cruzi, or _-N-acetylgalactosamine (GalNAc), in mammals. In T. cruzi, these structures helps the parasite to interact with the infected host, while in vertebrates the functions of mucins range from being protective barriers to providing lubrication for epithelial cells. In cancer-related mucins, however, altered glycosylation is a common feature, being verified the presence of mono- and disaccharide structures known as TN and TF antigens, respectively. Therefore, this work presents the synthesis of the glycopeptide NH2[_Gal]-(Thr)2- [_GalNAc]-(Thr)2-[_GlcNAc]-(Thr)3GlyOH 1, related to T. cruzi and cancer mucins, which can be useful for development of new therapeutics, like vaccines, against infectious and tumoral processes.

Abstract:

Download (PDF)

Palavras-chave: mucins, glycopeptide, solid-phase synthesis,

Palavras-chave: ,

DOI: 10.5151/chempro-14bmos-R0113-1

Referências bibliográficas
  • [1] 1 Buscaglia, C. A.; Campo, V. A.; Frasch, A. C. C.; DiNoia, J. M. Nat. Rev. Microbiol. 2006, 4, 229.
  • [2] 2 Brocke, C.; Kunz, H. Bioorg. Med. Chem. 2002, 10, 3085.
  • [3] 3 Campo, V. L.; Carvalho, I.; Allman, S.; Davis, B. G.; Field, R. A. Org. Biomol. Chem. 2007, 5, 2645.
Como citar:

Campo, Vanessa Leiria; Carvalho, Ivone; Baruffi, Marcelo Dias; "Chemical synthesis of glycopeptide related to T. cruzi and cancer mucins", p. 113 . In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 1, Setembro.2013. São Paulo: Blucher, 2013.
ISSN 2318-4043, DOI 10.5151/chempro-14bmos-R0113-1

últimos 30 dias | último ano | desde a publicação


downloads


visualizações


indexações