Chemoenzymatic one-pot synthesis of chiral disubstituted 1,2,3-triazoles in aqueous media

Chemoenzymatic one-pot synthesis of chiral disubstituted 1,2,3-triazoles in aqueous media

Oliveira, Camila de Souza de; Omori, Álvaro Takeo

Abstract:

The skeleton of substituted triazoles is present in many biologically active compounds, and most of them are commercially available for pharmaceutical purposes. Several methods for the preparation of this class of heterocycles are available. In this work, we established a one-pot two step procedure, combining the 1,3-dipolar cycloaddition and an enantioselective reduction mediated by Daucus carota root (carrot).

The skeleton of substituted triazoles is present in many biologically active compounds, and most of them are commercially available for pharmaceutical purposes. Several methods for the preparation of this class of heterocycles are available. In this work, we established a one-pot two step procedure, combining the 1,3-dipolar cycloaddition and an enantioselective reduction mediated by Daucus carota root (carrot).

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DOI: 10.5151/chempro-14bmos-R0186-1

Referências bibliográficas

• [1] 1. Melo, J. O. F.; Donnici, C. L.; Augusti, R.; Ferreira, V. F.; Souza, C. B. V.; Ferreira, M. L. G. e Cunha, A. C. Quim. Nova, 2006, 29, 569.
• [2] 2. Rostovtsev, V. V.; Green, L.G.; Fokin, V. V.; Sharpless, B. Angew. Chem. Int. 2002, 41, 2597.
• [3] 3. Comasseto, J.V.; Omori, A.T.; Porto, A.L.M.; Andrade, L.H. Tetrahedron Lett. 2004, 45, 473.

Como citar:

Oliveira, Camila de Souza de; Omori, Álvaro Takeo; "Chemoenzymatic one-pot synthesis of chiral disubstituted 1,2,3-triazoles in aqueous media", p-186-186. In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 1, Setembro.2013. São Paulo: Blucher, 2013.
ISSN 23184043, DOI 10.5151/chempro-14bmos-R0186-1