Dezembro 2013 vol. 1 num. 2 - Brazilian Meeting on Organic Synthesis 2013

Abstract - Open Access.

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Chemoselective Transformations for Bioimaging and Targeted Therapeutics

Bernardes, Gonçalo J. L. ;

Abstract:

Covalent protein modification is a key instrument in Chemical Biology: attachment of biophysical probes enable protein tracking and imaging; attachment of lipids to small therapeutic peptides extends their half-life in circulation; and protein conjugates are important biologic targets for the treatment of human diseases. In addition, proteins are modified after translation, increasingly significantly their structural complexity and functional capability. The use of efficient, complete, chemo- And regioselective methods in benign aqueous systems offers ways to redesign the structure and function of proteins of biological and therapeutic interest. This abstract features examples of (a) precise and controlled methods for site-specific protein labeling in vitro; (b) development of chemically-defined, traceless therapeutic proteins for cancer therapy and (c) controlled delivery of therapeutic CO using chemically-defined carbonyl metalloproteins.

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Palavras-chave: Aqueous reactions, site-selective protein modification, targeted therapeutics,

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DOI: 10.5151/chempro-15bmos-2-Bernardes_Template_15th_BMOS

Referências bibliográficas
  • [1] (1) Bernardes, G. J. L.; Chalker, J. M.; Errey, J. C.; Davis, B. G. J. Am. Chem. Soc. 2008, 130, 5052-5053.
  • [2] (2) Chalker, J. M.; Bernardes, G. J. L.; Davis, B. G. Acc. Chem. Res. 2011, 44, 730-741.
  • [3] (3) Bernardes, G. J. L.; Casi, G.; Trüssel, S.; Hartmann, I.; Schwager, K.; Scheuermann, J.; Neri, D. Angew. Chem. Int. Ed. 2012, 51, 941-944.
  • [4] (4) Steiner, M.; Hartmann, I.; Perrino, E.; Casi, G.; Brighton, S.; Jelesarov, I.; Bernardes, G. J. L.; Neri, D. Chem. Sci. 2013, 4, 297-302.
  • [5] (5) Bernardes, G. J. L.; Steiner, M.; Hartmann, I.; Neri, D.; Casi, G. Nat. Protocols 2013, 8, 2079-2089.
  • [6] (6) Santos-Silva, T.; Mukhopadhyay, A.; Seixas, J. D.; Bernardes, G. J. L.; Romão, C. C.; Romão, M. J. J. Am. Chem. Soc. 2011, 133, 1192-1195.
  • [7] (7) Romão, C. C.; Blättler, W. A.; Seixas, J. D.; Bernardes, G. J. L. Chem. Soc. Rev. 2012, 41, 3571-3583.
  • [8] (8) Pena, A. C.; Penacho, N.; Mancio-Silva, L.; Neres, R.; Seixas, J. D.; Fernandes, A. C.; Romão, C. C.; Mota, M. M.; Bernardes, G. J. L.; Pamplona, A. Antimicrob. Agents Chemother. 2012, 56, 1281-1290.
Como citar:

Bernardes, Gonçalo J. L.; "Chemoselective Transformations for Bioimaging and Targeted Therapeutics", p. 312 . In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 2, Dezembro.2013. São Paulo: Blucher, 2013.
ISSN 2318-4043, DOI 10.5151/chempro-15bmos-2-Bernardes_Template_15th_BMOS

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