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This paper aims to link human's emotions and cognition to the built environmentto improve the user's mental health and well-being. It focuses on cyber-physicaladaptive spaces that can respond to the user's physiological and psychologicalneeds based on their biological and neurological data. Through artificialintelligence and affective computing, this paper seeks to create user-orientedspaces that can learn from occupant's behavioral patterns in real-time, reduceuser's anxiety and depression, enhance environmental quality, and promote moreflexible human-centered designs for people with mental/physical disabilities. Toachieve its objectives, this research integrates tangible computingdevices/interfaces, robotic self-adjusting structures, interactive systems of control,programmable materials, human behavior, and a sensory network. Throughembedded responsiveness and material intelligence, the goal is to blur the linesbetween the physical, digital, and biological spheres and create cyber-physicalspaces that can ``feel'' and be controlled by the user's mind and feelings.