Setembro 2013 vol. 1 num. 1 - Brazilian Meeting on Organic Synthesis 2011

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Furanofurone frameworks from disacharides: synthetic studies

Novaes, Luiz Fernando Toneto ; Melo, Leandro Vilela de ; Baptistella, Lúcia Helena Brito ;

Abstract:

Molecules with furanolactones frameworks have been the target of our synthetic studies for same years. Here we report our recent results related to the use of the abundant and low cost disaccharide lactose for the preparation of new furanofurone compounds. Bicycles like the furanofurone 2 and the furano-pirone 3 may present an interesting biological activity, since they have structural similarities with natural products active against human tumor cells. Both 2 and 3 present an α,β-unsaturated carbonyl system, a functional group that, in a general way, may increase some antitumoral properties.

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Palavras-chave: intramolecular Wittig reactions, disaccharides, furanofurones,

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DOI: 10.5151/chempro-14bmos-R0183-1

Referências bibliográficas
  • [1] 1 Fang, X..; Anderson, J. E.; Chang, C.; McLaughlin, J. L. Tetrahedron. 1991, 47, 975
  • [2] 2 Whistler, R.L.; BeMiller, J.N. Methods in Carbohydrate Chemistry, vol II, 1963; Academic Press: NY; pp. 477-479
Como citar:

Novaes, Luiz Fernando Toneto; Melo, Leandro Vilela de; Baptistella, Lúcia Helena Brito; "Furanofurone frameworks from disacharides: synthetic studies", p. 183 . In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 1, Setembro.2013. São Paulo: Blucher, 2013.
ISSN 2318-4043, DOI 10.5151/chempro-14bmos-R0183-1

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