Janeiro 2014 vol. 1 num. 1 - I International Symposium in Neuroscience Meeting
Abstract - Open Access.
NDD.06. Effects of a sulfated agaran from red seaweed Gracilaria cornea in 6-OHDA hemi-parkinsonian rats
SOUZA, R.B. ; FROTA, .A.F. ; SOUZA, R.S. ; AGUIAR, L.M.V.B. ; BENEVIDES, N.M.B. ;
Abstract:
Animal models of PD induced by the neurotoxin 6-hydroxydopamine (6- OHDA) show locomotion and behavioral alterations mostly caused by the oxidative and inflammatory process induced by this neurotoxin. Sulfated agaran is a polysaccharide with sulfate groups found in the red seaweed Gracilaria cornea (SA). Recently, a study with SA showed anti-inflammatory effects and absence of toxic effects in vivo. The aim of this work was to evaluate the neuroprotective effects of SA after behavioral and locomotion alterations-induced by 6-OHDA intrastriatal injection in rats and to evaluate the safety of the intraestriatal administration of this polysaccharide in vivo.
Abstract:
Palavras-chave: Agaran sulfated, 6-hydroxydopamine, Safety,
Palavras-chave:
DOI: 10.5151/isnm-sine30
Referências bibliográficas
Como citar:
SOUZA, R.B.; FROTA, .A.F.; SOUZA, R.S.; AGUIAR, L.M.V.B.; BENEVIDES, N.M.B.; "NDD.06. Effects of a sulfated agaran from red seaweed Gracilaria cornea in 6-OHDA hemi-parkinsonian rats", p. 35 . In: In I International Symposium in Neuroscience Meeting, 2013 [Blucher Neuroscience Proceedings n.1 v.1].
São Paulo: Blucher,
2014.
ISSN 2357-772x,
DOI 10.5151/isnm-sine30
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