NDD.06. Effects of a sulfated agaran from red seaweed Gracilaria cornea in 6-OHDA hemi-parkinsonian rats

NDD.06. Effects of a sulfated agaran from red seaweed Gracilaria cornea in 6-OHDA hemi-parkinsonian rats

SOUZA, R.B.; FROTA, .A.F.; SOUZA, R.S.; AGUIAR, L.M.V.B.; BENEVIDES, N.M.B.

Abstract:

Animal models of PD induced by the neurotoxin 6-hydroxydopamine (6- OHDA) show locomotion and behavioral alterations mostly caused by the oxidative and inflammatory process induced by this neurotoxin. Sulfated agaran is a polysaccharide with sulfate groups found in the red seaweed Gracilaria cornea (SA). Recently, a study with SA showed anti-inflammatory effects and absence of toxic effects in vivo. The aim of this work was to evaluate the neuroprotective effects of SA after behavioral and locomotion alterations-induced by 6-OHDA intrastriatal injection in rats and to evaluate the safety of the intraestriatal administration of this polysaccharide in vivo.

Animal models of PD induced by the neurotoxin 6-hydroxydopamine (6- OHDA) show locomotion and behavioral alterations mostly caused by the oxidative and inflammatory process induced by this neurotoxin. Sulfated agaran is a polysaccharide with sulfate groups found in the red seaweed Gracilaria cornea (SA). Recently, a study with SA showed anti-inflammatory effects and absence of toxic effects in vivo. The aim of this work was to evaluate the neuroprotective effects of SA after behavioral and locomotion alterations-induced by 6-OHDA intrastriatal injection in rats and to evaluate the safety of the intraestriatal administration of this polysaccharide in vivo.

Palavras-chave:

DOI: 10.5151/isnm-sine30

Como citar:

SOUZA, R.B.; FROTA, .A.F.; SOUZA, R.S.; AGUIAR, L.M.V.B.; BENEVIDES, N.M.B.; "NDD.06. Effects of a sulfated agaran from red seaweed Gracilaria cornea in 6-OHDA hemi-parkinsonian rats", p-35-35. In: In I International Symposium in Neuroscience Meeting, 2013 [Blucher Neuroscience Proceedings n.1 v.1]. São Paulo: Blucher, 2014.
ISSN 2357772x, DOI 10.5151/isnm-sine30