Setembro 2013 vol. 1 num. 1 - Brazilian Meeting on Organic Synthesis 2011

Abstract - Open Access.

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New Approaches to Indoles and Indole Alkaloids

Wipf, Peter ; Petronijevic, Filip ;

Abstract:

Second only to pyridines, indoles are among the most common aromatic scaffolds present in bioactive molecules. The 5-hydroxy indole moiety alone has currently 10,500 substructure hits Among the many indole-containing alkaloid scaffolds, ergot alkaloids comprise a notable group of natural products of great biological activities. The striking biological properties of indoles and challenging polycyclic molecular architectures and wide spectrum of physiological activities of indole derivatives have attracted organic chemists for decades. In spite of all the synthetic approaches published to date, there is still opportunity and need for novel synthetic strategies that can harness the unique chemical diversity of indole derivatives.

Abstract:

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Palavras-chave: indoles, Diels-Alder cycloaddition, alkaloids,

Palavras-chave: ,

DOI: 10.5151/chempro-14bmos-R0388-1

Referências bibliográficas
  • [1] 1 Petronijevic, F.; Timmons, C.; Cuzzupe, A.; Wipf, P. Chem. Commun. 2009, 1, 104.
  • [2] 2 Petronijevic, F.; Wipf, P. J. Am. Chem. Soc. 2011, 133, in press.
Como citar:

Wipf, Peter; Petronijevic, Filip; "New Approaches to Indoles and Indole Alkaloids", p. 388 . In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 1, Setembro.2013. São Paulo: Blucher, 2013.
ISSN 2318-4043, DOI 10.5151/chempro-14bmos-R0388-1

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