Setembro 2013 vol. 1 num. 1 - Brazilian Meeting on Organic Synthesis 2011

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One-pot Procedure to Prepare 2-Pyridil-2-oxazolines

Wendler, Edison P. ; Carmona*, Rafaela C. ; Santos, Alcindo A. Dos ;

Abstract:

Economical and efficient synthetic design of optically active chiral ligands for highly enantioselective transformations continue to be one of the most challenging tasks in asymmetric synthesis. The 2-oxazoline ring can be found in biologically active natural products and pharmaceuticals. In addition their chiral derivatives are widely used as ligands or chiral pools in asymmetric synthesis. There are a myriad of reactions and transformations stereoselectivilly-assisted by chiral oxazolines as for instance lactone synthesis, cyclopropanation, aziridination, Diels-Alder cycloaddition, allylic substitution, among others. In face of its large application, the development of practical, economically attractive as well as environmental benign methods to prepare 2- oxazolines is constantly desirable. In this work we describe a one-pot procedure to prepare 2-pyridil-2-oxazolines by reacting 2-cyanopyridine with chiral amino alcohols catalyzed by zinc acetate under pressure.

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Palavras-chave: 2-pyridil-2-oxazolines, chiral ligands, one-pot procedure,

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DOI: 10.5151/chempro-14bmos-R0205-2

Referências bibliográficas
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Como citar:

Wendler, Edison P.; Carmona*, Rafaela C.; Santos, Alcindo A. Dos; "One-pot Procedure to Prepare 2-Pyridil-2-oxazolines", p. 205 . In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 1, Setembro.2013. São Paulo: Blucher, 2013.
ISSN 2318-4043, DOI 10.5151/chempro-14bmos-R0205-2

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