SCNS.05. Effect of compounds isolated from plants on 6-OHDA-induced cytotoxicity in cell culture model.

SCNS.05. Effect of compounds isolated from plants on 6-OHDA-induced cytotoxicity in cell culture model.

RODRIGUES, P.A.; MORAIS, S.M.; VIEIRA, I.G.P.; ANDRADE, G.M.

Abstract:

Parkinson''s disease (PD) is the second more common neurodegenerative disorder affecting approximately 1 % of the world population and is mainly characterized by progressive and selective depletion of dopamine neurons in the substantia nigra. The 6-hydroxydopamine (6-OHDA) is a neurotoxin that acts on catecholaminergic neurons, through the formation of reactive oxygen species (ROS) and inhibition of the complex I of the electron transport chains. Excessive production of ROS may lead to oxidative stress with loss of cellular functions and finally leading to cell death. The aim of this study was to investigate the cytoprotective activity of 18 substances of various chemical classes, isolated from plants, on 6-OHDA-induced cytotoxicity in PC12 cells.

Parkinson''s disease (PD) is the second more common neurodegenerative disorder affecting approximately 1 % of the world population and is mainly characterized by progressive and selective depletion of dopamine neurons in the substantia nigra. The 6-hydroxydopamine (6-OHDA) is a neurotoxin that acts on catecholaminergic neurons, through the formation of reactive oxygen species (ROS) and inhibition of the complex I of the electron transport chains. Excessive production of ROS may lead to oxidative stress with loss of cellular functions and finally leading to cell death. The aim of this study was to investigate the cytoprotective activity of 18 substances of various chemical classes, isolated from plants, on 6-OHDA-induced cytotoxicity in PC12 cells.

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DOI: 10.5151/isnm-sine10

Como citar:

RODRIGUES, P.A.; MORAIS, S.M.; VIEIRA, I.G.P.; ANDRADE, G.M.; "SCNS.05. Effect of compounds isolated from plants on 6-OHDA-induced cytotoxicity in cell culture model.", p-15-15. In: In I International Symposium in Neuroscience Meeting, 2013 [Blucher Neuroscience Proceedings n.1 v.1]. São Paulo: Blucher, 2014.
ISSN 2357772x, DOI 10.5151/isnm-sine10