Setembro 2013 vol. 1 num. 1 - Brazilian Meeting on Organic Synthesis 2011

Abstract - Open Access.

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Search for an enzymatic approach to achieve the enantiomeric enrichment of b-borylated carboxylic esters

Reis, Joel S. ; Andrade, Leandro H. ;

Abstract:

Lipases are the most used enzymes in organic chemistry. Their ability of enantiomers recognition by these biocatalysts represents a useful tool to synthesis of enantiomerically enriched compounds. Additionally, boron-containing compounds have increased the interest of scientists for being important building blocks of bioactive substances. The organoboron compounds are employed mainly in the Suzuki-Miyaura cross-coupling reactions. Herein, we are focused on development of an enzymatic way to enrich enantiomerically boroncontaining carboxylic esters, catalyzed by lipases.

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Palavras-chave: borylated, hydrolysis, transesterification,

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DOI: 10.5151/chempro-14bmos-R0101-1

Referências bibliográficas
  • [1] 1 Faber, K. Biotransformations in Organic Chemistry, Springer-Verlag, Berlin, 5th Ed., 2004.
  • [2] 2 Hall, D. G., Boronic Acids: Preparation, Aplications in Organic Synthesis and Medicine. Wiley-VHC: Weinheim, 2005.
  • [3] 3 Miyaura, N.; Suzuki, A. Chem. Rev. 1995, 95, 2457-248
  • [4] 4 Mun, S.; Lee, J.; Yun, J. Org. Lett. 2006, 8, 4887-4889.
Como citar:

Reis, Joel S.; Andrade, Leandro H.; "Search for an enzymatic approach to achieve the enantiomeric enrichment of b-borylated carboxylic esters", p. 101 . In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 1, Setembro.2013. São Paulo: Blucher, 2013.
ISSN 2318-4043, DOI 10.5151/chempro-14bmos-R0101-1

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