X-RAY DIFFRACTION APPLIED TO THE CHARACTERIZATION OF THE FIXED DOSE COMBINATION TABLETS FOR THE TREATMENT OF TUBERCULOSIS

X-RAY DIFFRACTION APPLIED TO THE CHARACTERIZATION OF THE FIXED DOSE COMBINATION TABLETS FOR THE TREATMENT OF TUBERCULOSIS

Nogueira, L. P. P.; Raffin, F. N.; Ayala, A.P.

Full Article:

The powder x-ray diffraction (PXRD) can be used in pharmaceutical studies for characterization of medications, identification and quantification of polymorphs. Thus, this study aimed to verify the potential of the XRD technique to evaluate fixed-dose combination (FDC) tablets for the treatment of tuberculosis, as well as, the individual active pharmaceutical ingredients (APIs). In order to ensure the efficacy, safety and quality of a drug, it is needed the knowledge of the solid state properties of APIs used in the formulation. The investigated FDC tables were composed of rifampicin (RIF), isoniazid (ISO), pyrazinamide (PYR) and ethambutol (ETA). The PXRD technique was used to characterize and identify the different samples studied. Comparing different lots of the FDC, it was possible to differentiate each API, as well as the different polymorphs in the reference sample of the rifampicin.

The powder x-ray diffraction (PXRD) can be used in pharmaceutical studies for characterization of medications, identification and quantification of polymorphs. Thus, this study aimed to verify the potential of the XRD technique to evaluate fixed-dose combination (FDC) tablets for the treatment of tuberculosis, as well as, the individual active pharmaceutical ingredients (APIs). In order to ensure the efficacy, safety and quality of a drug, it is needed the knowledge of the solid state properties of APIs used in the formulation. The investigated FDC tables were composed of rifampicin (RIF), isoniazid (ISO), pyrazinamide (PYR) and ethambutol (ETA). The PXRD technique was used to characterize and identify the different samples studied. Comparing different lots of the FDC, it was possible to differentiate each API, as well as the different polymorphs in the reference sample of the rifampicin.

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DOI: 10.5151/phypro-sic100-029

Como citar:

Nogueira, L. P. P.; Raffin, F. N.; Ayala, A.P.; "X-RAY DIFFRACTION APPLIED TO THE CHARACTERIZATION OF THE FIXED DOSE COMBINATION TABLETS FOR THE TREATMENT OF TUBERCULOSIS", p-29-29. In: Proceedings of the International Symposium on Crystallography [Blucher Physics Proceedings, v.1, n.3]. São Paulo: Blucher, 2015.
ISSN 23582359, DOI 10.5151/phypro-sic100-029