Studies towards the synthesis of dictyolomides A and B, and 6-methoxydictyolomide

Studies towards the synthesis of dictyolomides A and B, and 6-methoxydictyolomide

Duarte, Patricia Domingos; Corrêa, Arlene G.

Abstract:

Leishmaniasis is a tropical disease caused by protozoa parasites of the genus Leishmania and remains a significant health issue in large part due to the lack of effective and affordable drugs and increasing resistance against existing drugs. 4-Quinolones, for example dictyolomides, have been reported as potential antileishmanial agents. In this work we describe the studies towards the synthesis of dictyolomides A and B, and 6- methoxydictyolomide which will be evaluated against Leishmania sp and determine the stereochemistry of the center 3’.

Leishmaniasis is a tropical disease caused by protozoa parasites of the genus Leishmania and remains a significant health issue in large part due to the lack of effective and affordable drugs and increasing resistance against existing drugs. 4-Quinolones, for example dictyolomides, have been reported as potential antileishmanial agents. In this work we describe the studies towards the synthesis of dictyolomides A and B, and 6- methoxydictyolomide which will be evaluated against Leishmania sp and determine the stereochemistry of the center 3’.

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DOI: 10.5151/chempro-14bmos-R0185-1

Referências bibliográficas

• [1] 1Jain, M.; Khan, S.I.; Tekwani, B.L.; Jacob, M.R.; Singh, S.; Singh, P.P.; Jain, R. Bioorg. Med. Chem.2005,13, 4458.
• [2] 2Ambrozin, A.R.P.; Leite, A.C.; Silva, M., et al. Pharmazie 2005, 60, 781.
• [3] 3 BaraldiI, P. T., et al. 11th BMOS, Canela – RS, 2005, Abstracts p. 231.
• [4] 4Kaslow, C.E.; Nix, S.J. J. Org. Chem. 1951,16, 895.
• [5] 5 Bates, R.W.; Song, P., Synthesis, 2009, 655.

Como citar:

Duarte, Patricia Domingos; Corrêa, Arlene G.; "Studies towards the synthesis of dictyolomides A and B, and 6-methoxydictyolomide", p-185-185. In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 1, Setembro.2013. São Paulo: Blucher, 2013.
ISSN 23184043, DOI 10.5151/chempro-14bmos-R0185-1