Setembro 2013 vol. 1 num. 1 - Brazilian Meeting on Organic Synthesis 2011
Abstract - Open Access.
Synthesis and antimicrobial evaluation of 4-aryl-4,5-dihydro- 1H-1,5-benzodiazepin-2-ol derivatives
Ochoa, Estael ; Canaan, Claudia ; Verdecia, Yamila ; Peralta, Edna Dória ; Calderón, Osmar ; Ramos, Raúl ; Seruto, Yeily ; Neto, Aristóteles Góes ; Alvarez, Heiddy Marquez ; Lucchese, Angélica Maria ;
Abstract:
Benzodiazepines (BDZ) derivatives constituted the first pharmacological entity coined with the term privileged structure, due to their large number of therapeutic and pharmacological properties. Besides the well-known Nervous Central System related properties (ansiolytic, hypnotic and anticonvulsant, among others), they had been found also useful as antibiotic, antiviral (HIV-1), antitumor or cardiovascular drugs. In the other hand 1,5- benzodiazepine moiety had been much less studied than 1,4-benzodiazepines counterparts. In this work, it is reported the synthesis, characterization and antimicrobiological evaluation of different 4-aryl-4,5-dihydro-1H-1,5-benzodiazepin- 2-ol derivatives.
Abstract:
Palavras-chave: 1, 5-benzodiazepines, microwave, antimicrobial,
Palavras-chave: ,
DOI: 10.5151/chempro-14bmos-R0049-1
Referências bibliográficas
- [1] Nicolaou K. C., Pfefferkorn J. A., Roecker A. J., Cao G.-Q., Barluenga S., Mitchell H. J., J. Am. Chem. Soc., 2000, 122, 9939.
- [2] Horton D. A., Bourne G. T., Smythe M. L.., Chem. Rev., 2003, 103(3), 893
Como citar:
Ochoa, Estael; Canaan, Claudia; Verdecia, Yamila; Peralta, Edna Dória; Calderón, Osmar; Ramos, Raúl; Seruto, Yeily; Neto, Aristóteles Góes; Alvarez, Heiddy Marquez; Lucchese, Angélica Maria; "Synthesis and antimicrobial evaluation of 4-aryl-4,5-dihydro- 1H-1,5-benzodiazepin-2-ol derivatives", p. 49 . In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 1, Setembro.2013.
São Paulo: Blucher,
2013.
ISSN 2318-4043,
DOI 10.5151/chempro-14bmos-R0049-1
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