Setembro 2013 vol. 1 num. 1 - Brazilian Meeting on Organic Synthesis 2011

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Synthesis and Citotoxicity Evaluation of 3-Cyano-2-aminocycloalkyl[ b]thiophene derivatives

MOURA, R.O. ; DE ARAÚJO, R.S.A. ; RIBEIRO, F.F. ; CRUZ, R.M.D. ; DE OLIVEIRA, J.G.B. ; DA-CRUZ, R.M.D. ; MONTEIRO, M.B. ; MENDONÇA JUNIOR, F.J.B. ;

Abstract:

The synthesis of new bioactive compounds requires preliminary testing to determine the toxicity and provide important indications of the feasibility of in vivo tests. The brine shrimp (Artemia salina) is a microcrustacean used as an animal model to determine the citotoxicity of synthetic compounds and natural products in lethality bioassays. This is a quickly and cheaply test with high correlation with other cytotoxicity bioassays. This study aims to synthesize and evaluate the citotoxicity of 2-amino- 3-cyano-cycloalkyl[b]thiophene derivatives which possessed significant antifungal activity in vitro, through the Artemia salina lethality bioassay.

Abstract:

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Palavras-chave: synthesis, cycloalkyl[b]thiophenes, Artemia salina, cytotoxicity,

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DOI: 10.5151/chempro-14bmos-R0288-2

Referências bibliográficas
  • [1] 1 Gewald, K.; Schinke, E.; Bottcher, H. Chem Ber. 1966, 94.
  • [2] 2 Meyer, B. N.; Ferrigni, N. R.; Putnam, L. B.; Jacobsen, L. B.; Nichols, D. E.; McLaughlin, J. L. Planta Medica. 1982, 45, 31.
  • [3] 3 Finey, D.J. Probit analysis. 3rd ed. Cambridge University Press, Cambridge, 1971.
Como citar:

MOURA, R.O.; DE ARAÚJO, R.S.A.; RIBEIRO, F.F.; CRUZ, R.M.D.; DE OLIVEIRA, J.G.B.; DA-CRUZ, R.M.D.; MONTEIRO, M.B.; MENDONÇA JUNIOR, F.J.B.; "Synthesis and Citotoxicity Evaluation of 3-Cyano-2-aminocycloalkyl[ b]thiophene derivatives", p. 288 . In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 1, Setembro.2013. São Paulo: Blucher, 2013.
ISSN 2318-4043, DOI 10.5151/chempro-14bmos-R0288-2

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