Setembro 2013 vol. 1 num. 1 - Brazilian Meeting on Organic Synthesis 2011

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Synthesis and Docking of new (2-(2,5-dimethoxyphenyl)-1Hbenzo[ d]imidazol-1-yl)(aryl)methanone derivatives designed as novel cannabinoid CB1 receptor antagonists.

Espinosa-Bustos, C ; Lagos, C. F. ; Romero-Parra, J. ; Mella-Raipán, J. ; Pessoa- Mahana, H. ; Recabarren-Gajardo, G. ; Pessoa-Mahana, C. D. ;

Abstract:

The endocannabinoid system has been known to mediate a complex array of biological effects. These effects are regulated through at least two distinct Gprotein coupled receptors, the CB1 and CB2 receptor . Specifically, the antagonists of the CB1 receptor possess very useful applications, particularly in the obesity treatment such as Rimonabant. In this work we inform the synthesis and docking studies of several (2-(2,5-dimethoxyphenyl)-1Hbenzo[ d]imidazol-1-yl)(aryl)methanone as potential CB1 receptor antagonists.

Abstract:

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Palavras-chave: benzimidazoles, cannabinoids, heterocycles,

Palavras-chave: ,

DOI: 10.5151/chempro-14bmos-R0169-1

Referências bibliográficas
  • [1] 1 M. P. Verbist, M. A. De Cleyn,M. Surkyn, E. Fraiponts, J. Aerssens, M. A. Nijsena H. J. M. Gijsena. Bioorg. Med. Chem. Lett. 2008, 18, 2574.
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  • [3] 3 D. Pessoa-Mahana, A. Núñez, C. Espinosa, J. Mella-Raipán, H. Pessoa-Mahana. J. Braz. Chem. Soc. 2010 21, 6
Como citar:

Espinosa-Bustos, C; Lagos, C. F.; Romero-Parra, J.; Mella-Raipán, J.; Pessoa- Mahana, H.; Recabarren-Gajardo, G.; Pessoa-Mahana, C. D.; "Synthesis and Docking of new (2-(2,5-dimethoxyphenyl)-1Hbenzo[ d]imidazol-1-yl)(aryl)methanone derivatives designed as novel cannabinoid CB1 receptor antagonists.", p. 169 . In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 1, Setembro.2013. São Paulo: Blucher, 2013.
ISSN 2318-4043, DOI 10.5151/chempro-14bmos-R0169-1

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