Dezembro 2013 vol. 1 num. 2 - Brazilian Meeting on Organic Synthesis 2013

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Synthesis and identification by GC-MS of 3-(pyridin-2-yl)- thiazolidinethiones

Cunico, W. ; Siqueira, G.M. ; Mimbarcas, L.F. ; Campos Jr, J.C. ; Bierhals, M.P. ;

Abstract:

Thiazolidinones are an important group of heterocyclic compounds that has attracted considerable attention due facile synthesis and wide range of pharmaceutical activities. Transformation of a carbonyl functional group into thiocarbonyl has been an important interest to synthetic organic chemists for many years. Lawesson’s Reagent is the most widely used agent for such a transformation. Besides, the bioisosteric replacement of carbonyl group by thiocarbonyl may increase biological activity such as in thionation of 4-thioxo-thiazolidin- 2-ones. With this, the purpose of this study was to synthesize new compounds thiocarbonyl derivatives (thiazolidinethiones) arising from 3- (pyridin-2-yl)-thiazolidinones using Lawesson’s Reagent as thionating agent and identified by GC-MS.

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Palavras-chave: thiazolidinones, thionation, thiazolidinethiones,

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DOI: 10.5151/chempro-15bmos-BMOS2013_2013915213437

Referências bibliográficas
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Como citar:

Cunico, W.; Siqueira, G.M.; Mimbarcas, L.F.; Campos Jr, J.C.; Bierhals, M.P.; "Synthesis and identification by GC-MS of 3-(pyridin-2-yl)- thiazolidinethiones", p. 276 . In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 2, Dezembro.2013. São Paulo: Blucher, 2013.
ISSN 2318-4043, DOI 10.5151/chempro-15bmos-BMOS2013_2013915213437

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