Dezembro 2013 vol. 1 num. 2 - Brazilian Meeting on Organic Synthesis 2013

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Synthesis and reactivity of pyrazolo-pyridone ring, an understudied heteroaromatic scaffold

Júnior, Paulo Eliandro da Silva ; Ganesan, A. ; Dale, James ; Emery, Flavio ;

Abstract:

The chemical structural space of all possible compounds is vast, with more than 1062 compounds with molecular weights below 500 Da. Heteroaromatic rings are common in bioactive molecules and both medicinal and agro chemists have exploited these scaffolds to provide high value materials, for example Glivec, an anti cancer drug, and Exjade to treat iron overload. However, only a small fraction of the heteroaromatic space is currently exploited for drug discovery, and has established synthetic routes to access them, supporting a scenario in which is shown the disclosure of new heterocyclic skeletons follows a rate of 5-10 per year. The main scope of this work is to study the synthesis of underexplored heterocyclic scaffold, based on a recent computational study, which listed interesting yet under represented heterocyclic skeletons with drug discovery potential.

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Palavras-chave: pyrazolo-pyridone, N-acyl-N-nitroso rearrangement, heterocycle,

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DOI: 10.5151/chempro-15bmos-BMOS2013_2013915143915

Referências bibliográficas
  • [1] 1 Leeson, P.D.; Davis, A.M.; Steele, J. Drug Discovery Today: Technol.
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Como citar:

Júnior, Paulo Eliandro da Silva; Ganesan, A.; Dale, James; Emery, Flavio; "Synthesis and reactivity of pyrazolo-pyridone ring, an understudied heteroaromatic scaffold", p. 257 . In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 2, Dezembro.2013. São Paulo: Blucher, 2013.
ISSN 2318-4043, DOI 10.5151/chempro-15bmos-BMOS2013_2013915143915

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