Synthesis of 7-aryl(alkyl)1,2,4-triazolo[1,5-a]pyrimidine Using Conventional Methods

Synthesis of 7-aryl(alkyl)1,2,4-triazolo[1,5-a]pyrimidine Using Conventional Methods

Scapin, Elisandra; Buriol, Lilian; München, Taiana Scalco; Frizzo, Clarissa Piccinin; Marzari, Mara; Martins, Marcos A. P.

Abstract:

The chemistry of 1,2,4-triazolo[1,5-a]pyrimidine derivatives has been of considerable interest of medicinal and agricultural chemistry for many years. Two very important herbicides, Flumetsulam and Metosulam show acetohydroxyacid synthase inhibitor properties. Other [1,2,4]-triazolo[1,5- a]pyrimidines with antiparasitic, antimicrobial and anticancer activities also are documented. The more related route to 1,2,4-triazolo[1,5-a]pyrimidine is by use of unsymmetrical vinylogous iminium salts. Other route know-well are cyclocondensation reactions of aminoazoles with, _,_-unsaturated ketoesters and aldehydes in multicomponent reactions. In this context, the objective of this work is synthetized 7-aryl(alkyl)1,2,4-triazolo[1,5- a]pyrimidine from ciclocondensation reaction of _- dimethylaminovinyl ketones and 3-amino-1,2,4- triazole.

The chemistry of 1,2,4-triazolo[1,5-a]pyrimidine derivatives has been of considerable interest of medicinal and agricultural chemistry for many years. Two very important herbicides, Flumetsulam and Metosulam show acetohydroxyacid synthase inhibitor properties. Other [1,2,4]-triazolo[1,5- a]pyrimidines with antiparasitic, antimicrobial and anticancer activities also are documented. The more related route to 1,2,4-triazolo[1,5-a]pyrimidine is by use of unsymmetrical vinylogous iminium salts. Other route know-well are cyclocondensation reactions of aminoazoles with, _,_-unsaturated ketoesters and aldehydes in multicomponent reactions. In this context, the objective of this work is synthetized 7-aryl(alkyl)1,2,4-triazolo[1,5- a]pyrimidine from ciclocondensation reaction of _- dimethylaminovinyl ketones and 3-amino-1,2,4- triazole.

Palavras-chave:

DOI: 10.5151/chempro-14bmos-R0028-1

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Como citar:

Scapin, Elisandra; Buriol, Lilian; München, Taiana Scalco; Frizzo, Clarissa Piccinin; Marzari, Mara; Martins, Marcos A. P.; "Synthesis of 7-aryl(alkyl)1,2,4-triazolo[1,5-a]pyrimidine Using Conventional Methods", p-28-28. In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 1, Setembro.2013. São Paulo: Blucher, 2013.
ISSN 23184043, DOI 10.5151/chempro-14bmos-R0028-1