Synthesis of Carbonohydrazideamide, Carbonohydrazidethioamide with potential biological activity

Synthesis of Carbonohydrazideamide, Carbonohydrazidethioamide with potential biological activity

Tozatti, Camila S. S.; Santos, Edson A. dos; Coelho, Narcimário P.; Santos, Maria Cristina P. dos; Silva, Michael J. V. da; Gonçalves, Davana S.; Basso, Ernani A.

Abstract:

Semicarbazones, carbonohydrazides, thiosemicarbazides and semicarbazides are reported to possess a wide range of biological activities, such as antimicrobial, fungicidal and antitumor. However, to the best of our knowledge, carbonohydrazideamide and carbonohydrazidethioamide are not reported anywhere, despite the structural similarity with the functional groups mentioned above (figure 1). With the aim of developing a route for biologically active compounds, herein we report the synthesis of a series of Carbonohydrazideamide and carbonohydrazidethioamide

Semicarbazones, carbonohydrazides, thiosemicarbazides and semicarbazides are reported to possess a wide range of biological activities, such as antimicrobial, fungicidal and antitumor. However, to the best of our knowledge, carbonohydrazideamide and carbonohydrazidethioamide are not reported anywhere, despite the structural similarity with the functional groups mentioned above (figure 1). With the aim of developing a route for biologically active compounds, herein we report the synthesis of a series of Carbonohydrazideamide and carbonohydrazidethioamide

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DOI: 10.5151/chempro-15bmos-BMOS2013_201391017916

Referências bibliográficas

• [1] Jafri, L. et al. Chem Biol Drug Des 2012, 79,950–959;
• [2] [2] Gammal, O.A. E. et al. Journal of Molecular Structure 2012, 1020, 6–15;
• [3] Leite, A.C.L. et al. Acta Farm. Bonaerense 2004, 23, 117-122;
• [4] Yousef, T.A. et al. Int. J. Med. Med. Sci 2011, 3, 37-46;
• [5] Gokce, M. et al. Journal of Faculty of Pharmacy of Gazi University 2000, 17, 61-70;
• [6] Umamatheswari, S. et al. European Journal of Medicinal Chemistry 2011, 46, 1415-1424;
• [7] Li, Z. et al. Synthetic Communications 2006, 36, 2613–2619.

Como citar:

Tozatti, Camila S. S.; Santos, Edson A. dos; Coelho, Narcimário P.; Santos, Maria Cristina P. dos; Silva, Michael J. V. da; Gonçalves, Davana S.; Basso, Ernani A.; "Synthesis of Carbonohydrazideamide, Carbonohydrazidethioamide with potential biological activity", p-68-68. In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 2, Dezembro.2013. São Paulo: Blucher, 2013.
ISSN 23184043, DOI 10.5151/chempro-15bmos-BMOS2013_201391017916