Dezembro 2013 vol. 1 num. 2 - Brazilian Meeting on Organic Synthesis 2013

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Synthesis of Diselenide Based Picolylamide Derivatives: Biologically Potential Compounds

Rafique, Jamal ; , ; Saba, Sumbal ; Canto, Rômulo F. S. ; Hassan, Waseem ; Rocha, João B. T. ; Braga, Antonio L. ;

Abstract:

Interest in synthetic organoselenium compounds has been growing since the 1970s, when many reports described the identification of various selenoproteins, which are involved in a wide number of physiological processes in mammals, such as antioxidant defense, thyroid hormone production and immune responses. There are many reports regarding the biological importance of diselenides having amide bond. The presence of amide bond in close proximity of selenium not only improves the biological activity but also improves the stability of the compound2. Thus, according to our interest in bioactive organoselenium compounds, herein, we describe the synthesis of diselenide based picolylamides 1 (Figure 1), as potentially bioactive molecules.

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Palavras-chave: Picolylamide, diselenide, antioxidant,

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DOI: 10.5151/chempro-15bmos-BMOS2013_2013822125235

Referências bibliográficas
  • [1] 1 Jacob, C.; Giles, G. I.; Giles, N. M. e Sies H., Angew. Chem. Int. Ed.,
  • [2] 2003, 42, 474
  • [3] 2 Braga, A. L. e Rafique, J. in Patai's Chemistry of Functional Groups), ed
  • [4] Z. Rappoport, John Wiley And Sons, Ltd., Chichester, 2013, vol.
  • [5] 3 Mugesh, G.; du Mont, W.-W. e Sies, H. Chem. Rev. 2001, 101, 212
  • [6] 4 Kawasoko, C. Y.; Foletto, P.; Rodrigues, O. E. D.; Dornelles, l.; Schwab,
  • [7] R. S. Braga, A. L. Org. Biomol. Chem. 2013,11, 5173.
Como citar:

Rafique, Jamal; , ; Saba, Sumbal; Canto, Rômulo F. S.; Hassan, Waseem; Rocha, João B. T.; Braga, Antonio L.; "Synthesis of Diselenide Based Picolylamide Derivatives: Biologically Potential Compounds", p. 196 . In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 2, Dezembro.2013. São Paulo: Blucher, 2013.
ISSN 2318-4043, DOI 10.5151/chempro-15bmos-BMOS2013_2013822125235

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