Dezembro 2013 vol. 1 num. 2 - Brazilian Meeting on Organic Synthesis 2013

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Synthesis of lactones and lactams analogues to rubrolides as inhibitors of Enterococcus faecalis biofilm formation

Pereira, Ulisses A. ; Barbosa, Luiz C. A. ; Maltha, Célia R. A. ; Demuner, Antônio Jacinto ; Pimenta, Andréa de L. ;

Abstract:

Biofilms are a bacterial communities enclosed within an extracellular matrix capable to survive to antibiotics treatments. It has been estimated that 65-80% of the microbial infections occurring in the human body are biofilm-related. Therefore, identifying substances that are able to inhibit biofilm formation constitutes a promising approach for the development of new drugs. In this work, analogues to rubrolides, a class of natural γ-alkylidene-γ-lactones, and their corresponding lactams were synthesized and evaluated against E. faecalis biofilm formation.

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Palavras-chave: γ-lactams, γ-lactones, biofilm,

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DOI: 10.5151/chempro-15bmos-BMOS2013_2013814154045

Referências bibliográficas
  • [1] 1 Musk Jr, D. J.; Hergenrother, P. J. Curr. Med. Chem., 2006, 13, 2163.
  • [2] 2 Davies, D. Nat. Rev. Drug Discov., 2010, 2, 114.
  • [3] 3 Miao, S.; Andersen, R. J. J. Org. Chem., 56, 1991, 6275.
Como citar:

Pereira, Ulisses A.; Barbosa, Luiz C. A.; Maltha, Célia R. A.; Demuner, Antônio Jacinto; Pimenta, Andréa de L.; "Synthesis of lactones and lactams analogues to rubrolides as inhibitors of Enterococcus faecalis biofilm formation", p. 154 . In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 2, Dezembro.2013. São Paulo: Blucher, 2013.
ISSN 2318-4043, DOI 10.5151/chempro-15bmos-BMOS2013_2013814154045

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