Synthesis of New N,O-Acetals 2-Amino-1,4-naphthoquinones Derivatives Under Microwave Irradiation

Synthesis of New N,O-Acetals 2-Amino-1,4-naphthoquinones Derivatives Under Microwave Irradiation

Jordão, Alessandro K.; Rocha, David R. da; Ferreira, Vitor F.

Abstract:

Naphthoquinones are important natural substances that are widely distributed in different families of plants, fungi and some animals. The introduction of amino substituents onto the quinone moeity can exert influence on its redox properties, inducing oxidative stress in cells and alkylation of DNA. The aminoquinones are found in important bioactive compounds such as antitumor (1) and antimalarial (2) agents.

Naphthoquinones are important natural substances that are widely distributed in different families of plants, fungi and some animals. The introduction of amino substituents onto the quinone moeity can exert influence on its redox properties, inducing oxidative stress in cells and alkylation of DNA. The aminoquinones are found in important bioactive compounds such as antitumor (1) and antimalarial (2) agents.

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DOI: 10.5151/chempro-14bmos-R0062-1

Referências bibliográficas

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• [2] 2 Benites, J.; Valderrama, J A.; Bettega, K.; Pedrosa, R. C.; Calderon, P. B.; Verrax, J. Eur. J. Med. Chem. 2010, 45, 6052.
• [3] 3 Kapadia, G. J.; Azuine, M. A.; Balasubramanian, V.; Sridhar, R. Pharmacol. Res. 2001, 43, 363.
• [4] 4 Barluenga, J.; Bayón, A M.; Campos, P.; Asensio, G.; Gonzalez-Nuñez, E.; Molina, Y. J. J. Chem. Soc. Perkin. Trans. I 1988, 1631.
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Como citar:

Jordão, Alessandro K.; Rocha, David R. da; Ferreira, Vitor F.; "Synthesis of New N,O-Acetals 2-Amino-1,4-naphthoquinones Derivatives Under Microwave Irradiation", p-62-62. In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 1, Setembro.2013. São Paulo: Blucher, 2013.
ISSN 23184043, DOI 10.5151/chempro-14bmos-R0062-1