Setembro 2013 vol. 1 num. 1 - Brazilian Meeting on Organic Synthesis 2011

Abstract - Open Access.

Idioma principal

Synthesis of new trichloro(fluoro)methylated biheterocycles

Souto, Alynne A. ; Flores, Alex F. C. ; Malavolta, Juliana L. ; Doneda, Morgana ;

Abstract:

Among the chemical compounds used in the pharmaceutical and agrochemicals industry, most of them have a heterocyclic ring. Among these, pyrazoles and pyrimidines, which have large importance in the field of medicinal chemistry, stand out being used as anti-inflammatory, antibiotics, analgesics, antibacterial, antineoplastic, among other. Biheterocycles have two heterocyclic rings connected by an alkyl group, carbonyl derivatives or directly between themselves. Their importance in the chemical industry and pharmaceutical has already been reported, mainly being used as hypoglycemic agents. Thus, the objectives of this work are the synthesis and reactivity study of hidrazides, pyrimidines and pyrazoles synthesized in our laboratories.

Abstract:

Download (PDF)

Palavras-chave: heterocycles, hydrazides, pyrazole,

Palavras-chave: ,

DOI: 10.5151/chempro-14bmos-R0108-1

Referências bibliográficas
  • [1] 1 Jaiprakash, N. S.; Aniruddha, R. C.; Devanand, B. S., Bioorg. Med. Chem. Lett. 2011, 21, 444
  • [2] 2 (a) Lotti, B.; Vezossi, O.. Farmaco 1972, 24, 313. (b) Soliman, R.; Darwish, A. S. J. Med. Chem. 1983, 26, 1659. (c) Wright, J. B.; Dulin, W. E.; Markillie, J. H. J. Med. Chem. 1964, 7, 10
  • [3] 3 (a) Flores, A. F. C.; Pizzuti, L.; Brondani, S.; Rossato, M.; Zanatta, N.; Martins, M. A. P. J. Braz. Chem. Soc. 2007, 18, 1316. (b) Piovesan, L. A. Tese de Doutorado. Universidade Federal de Santa Maria 2009.
Como citar:

Souto, Alynne A.; Flores, Alex F. C.; Malavolta, Juliana L.; Doneda, Morgana; "Synthesis of new trichloro(fluoro)methylated biheterocycles", p. 108 . In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 1, Setembro.2013. São Paulo: Blucher, 2013.
ISSN 2318-4043, DOI 10.5151/chempro-14bmos-R0108-1

últimos 30 dias | último ano | desde a publicação


downloads


visualizações


indexações