Dezembro 2013 vol. 1 num. 2 - Brazilian Meeting on Organic Synthesis 2013

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Synthesis of novel 6-seleno-dihydropyrimidinones: Potentially bioactive compounds

Barbosa, Flavio A. R. ; Canto, Rômulo F. S. ; Braga, Antonio L. ;

Abstract:

Organoselenium compounds and dihydropyrimidinones (DHPMs) are biologically privileged classes of compounds due to its interactions with a wide range of molecular targets what leads to distinct pharmacological activities. Recent studies have shown that DHPMs are capable to act as anti-inflammatory and antitumoral agents.The same activities are described for organoselenium compounds, however, the mechanism of action of both classes are not supposed to be the same. Exploring the versatility of the Biginelli scaffold and the biological activities presented by organochalcogens, a series of novel potentially bioactive 6-seleno-dihydropyrimidinones was synthesized in this work.This new hybrid compounds are potential drug candidates, and we can also expect a possible synergism between the different pharmacophores

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Palavras-chave: organochalcogenides, selenocyanates, Biginelli compounds,

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DOI: 10.5151/chempro-15bmos-BMOS2013_2013819222620

Referências bibliográficas
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Como citar:

Barbosa, Flavio A. R.; Canto, Rômulo F. S.; Braga, Antonio L.; "Synthesis of novel 6-seleno-dihydropyrimidinones: Potentially bioactive compounds", p. 182 . In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 2, Dezembro.2013. São Paulo: Blucher, 2013.
ISSN 2318-4043, DOI 10.5151/chempro-15bmos-BMOS2013_2013819222620

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