Setembro 2013 vol. 1 num. 1 - Brazilian Meeting on Organic Synthesis 2011

Abstract - Open Access.

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Synthesis of Pimarane-type Diterpenes from Constituents of Copaiba Oil.

Sass, Daiane Cristina ; Heleno, Vladimir C. G. ; Silva, Aline Nazaré ; Silva, Simone Cavalcante ; Constantino., Mauricio Gomes ;

Abstract:

Pimarane-type diterpenes, such as pimara- 8,15-diene (1) and pimaradienoic acid (5) (figure 1), are mainly isolated from conifer oleoresin. This class of compounds has shown interesting biological activities, e.g. analgesic, anti-tumor, antiinflammatory, vasorelaxant, antimicrobial activities, anti-Alzheimer and antioxidant effects. Due to the importance of this class, several research groups have already proposed total synthesis of those substances. Thus, we decided to study the synthesis of these compounds from two main constituents of Copaiba oil, copalic acid (7) and ent-agathic acid (8) (figure 2).

Abstract:

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Palavras-chave: Pimaranes, Diterpenes, Copalic acid,

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DOI: 10.5151/chempro-14bmos-R0132-2

Referências bibliográficas
  • [1] 1 Jung, H. A. et al. Arch Pharm Res 2009, 32, 1399-1408.
  • [2] 2 .McCreadie, T. et al. J. Chem. Soc. 1971, 312-316.
Como citar:

Sass, Daiane Cristina; Heleno, Vladimir C. G.; Silva, Aline Nazaré; Silva, Simone Cavalcante; Constantino., Mauricio Gomes; "Synthesis of Pimarane-type Diterpenes from Constituents of Copaiba Oil.", p. 132 . In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 1, Setembro.2013. São Paulo: Blucher, 2013.
ISSN 2318-4043, DOI 10.5151/chempro-14bmos-R0132-2

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