Synthesis of Polyketide Fragments in Order to Study the Elaiophylin Biosynthesis

Synthesis of Polyketide Fragments in Order to Study the Elaiophylin Biosynthesis

Prediger, Patrícia; Dias., Luiz Carlos

Abstract:

Elaiophylin (1), a glycosidic polyketide, was first isolated from the cultures of Streptomyces melanosporus by Arcamone et al.1a and by Arai1b from a related microorganism. Elaiophylin is a 16- membered macrolide which displays a wide range of bioactivities such as antimicrobial, cell cycle inhibition, apoptosis induction, immunosuppressive, anthelmintic, inhibition of K+-dependent adenosine triphosphatases, and plant growth inhibition. Due to the pronounced activity showed by this macrolide, we are interested in to investigate its biosynthesis by analyzing the interaction between the elaiophylin enzyme thioesterase and the fragments 2-5.

Elaiophylin (1), a glycosidic polyketide, was first isolated from the cultures of Streptomyces melanosporus by Arcamone et al.1a and by Arai1b from a related microorganism. Elaiophylin is a 16- membered macrolide which displays a wide range of bioactivities such as antimicrobial, cell cycle inhibition, apoptosis induction, immunosuppressive, anthelmintic, inhibition of K+-dependent adenosine triphosphatases, and plant growth inhibition. Due to the pronounced activity showed by this macrolide, we are interested in to investigate its biosynthesis by analyzing the interaction between the elaiophylin enzyme thioesterase and the fragments 2-5.

Palavras-chave:

DOI: 10.5151/chempro-15bmos-BMOS2013_201391515128

Referências bibliográficas

• [1] 1 (a) Arcamone, F. M.; Bertazzoli, C.; Ghione, M.; Scotti, T. G. G. Microbiol. 1959, 7, 207. (b) Azalomycin, B.; Arai, M. J. Antibiot., Ser. A 1960, 13, 51.
• [2] 2 Hammann, P.; Kretzschmar, G.; Seibert, G. J. Antibiot., 1990, 43, 1431.
• [3] 3 The biological essays are in progress at University of Cambridge by Dr. Yongjun Zhou and Prof. Dr. Peter F. Leadlay.

Como citar:

Prediger, Patrícia; Dias., Luiz Carlos; "Synthesis of Polyketide Fragments in Order to Study the Elaiophylin Biosynthesis", p-88-88. In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 2, Dezembro.2013. São Paulo: Blucher, 2013.
ISSN 23184043, DOI 10.5151/chempro-15bmos-BMOS2013_201391515128