Setembro 2013 vol. 1 num. 1 - Brazilian Meeting on Organic Synthesis 2011

Abstract - Open Access.

Idioma principal

Synthesis of tacrine-lophine hybrids

Lopes, João Paulo B. ; Costa, Jessé S. da ; Russowsky, Dennis ; Ceschi, Marco Antonio ;

Abstract:

Our research group has been involved in the development of cholinesterases (ChEs) inhibitors as potential drugs of Alzheimer’s disease (AD). Tacrine (1) was the first approved ChEs inhibitor by the FDA for the treatment of AD, although its side effects, the search for tacrine hybrids is very important. The bis(7)-tacrine analogues linked by an alkylene chain (bis(n)-cognitin) were prepared and it was proved that these dimeric molecules of tacrine offered a much stronger potency. As part of our studies directed towards the synthesis and biological screening for compounds with ChEs inhibitory activity, we describe herein or studies on the synthesis of a new series of tacrine-lophine hybrids linked by an alkylene chain.

Abstract:

Download (PDF)

Palavras-chave: Synthesis, Tacrine, Lophine,

Palavras-chave: ,

DOI: 10.5151/chempro-14bmos-R0029-1

Referências bibliográficas
  • [1] 1Pisoni, D. S., da Costa, J. S.; Gamba, D.; Petzhold, C. L.; Borges, A. C. A.; Ceschi, M. A.; Lunardi, P.; Gonçalves, C. A. S.; Eur. J. Med. Chem. 2010, 45, 526..
  • [2] 2 Kozurkova, M.; Hamulakova, S.; Gazova, Z.; Paulikova, H.; Kristian, P ,Pharmaceuticals 2011, 4, 38
Como citar:

Lopes, João Paulo B.; Costa, Jessé S. da; Russowsky, Dennis; Ceschi, Marco Antonio; "Synthesis of tacrine-lophine hybrids", p. 29 . In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 1, Setembro.2013. São Paulo: Blucher, 2013.
ISSN 2318-4043, DOI 10.5151/chempro-14bmos-R0029-1

últimos 30 dias | último ano | desde a publicação


downloads


visualizações


indexações