Synthesis of tetrahydropiridines by one-pot multicomponent reaction using Niobium Pentaethoxide.

Synthesis of tetrahydropiridines by one-pot multicomponent reaction using Niobium Pentaethoxide.

Martins, L. M.; da Silva, B. H. S. T.; Silva-Filho, L. C.

Abstract:

Tetrahydropiridines derivatives (THP) and theirs analogues have high pharmacological potential. That potential is explained by the piperidine subunit, present in various natural alkaloids and biologically active synthetic drugs widely used in medicine and known as a good pharmacophore (figure 1). In this context, recently Misra and co-workers described excellent results obtained for antimalarial activity to THP derivatives. In this work, we describe our studies about the synthesis of THP derivatives by Multicomponent Reaction (MCR) catalyzed by Nb(OEt)5.

Tetrahydropiridines derivatives (THP) and theirs analogues have high pharmacological potential. That potential is explained by the piperidine subunit, present in various natural alkaloids and biologically active synthetic drugs widely used in medicine and known as a good pharmacophore (figure 1). In this context, recently Misra and co-workers described excellent results obtained for antimalarial activity to THP derivatives. In this work, we describe our studies about the synthesis of THP derivatives by Multicomponent Reaction (MCR) catalyzed by Nb(OEt)5.

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DOI: 10.5151/chempro-15bmos-BMOS2013_2013926121740

Referências bibliográficas

• [1] 1 Botté, C.Y.; Dubar, F.; McFadden, G. I.; Maréchal, E.; Biot, C.
• [2] Chem. Rev. 2012, 112, 1369.
• [3] 2Misra, M.; Pandey, S. K.; Pandey, V. P.; Pandey, J.; Tripathi, R.;
• [4] Tripathi, R. P. Bioorg. Med. Chem. 2009, 17, 625.
• [5] 3 Lacerda Jr., V.; dos Santos, D. A.; Silva-Filho, L. C.; Greco, S.
• [6] J.; dos Santos, R. B. Aldrichimica Acta 2012, 45, 19.

Como citar:

Martins, L. M.; da Silva, B. H. S. T.; Silva-Filho, L. C.; "Synthesis of tetrahydropiridines by one-pot multicomponent reaction using Niobium Pentaethoxide.", p-289-289. In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 2, Dezembro.2013. São Paulo: Blucher, 2013.
ISSN 23184043, DOI 10.5151/chempro-15bmos-BMOS2013_2013926121740