Dezembro 2013 vol. 1 num. 2 - Brazilian Meeting on Organic Synthesis 2013

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α,β-Unsaturated Diazoketones in Aza-Michael Additions - Application in the synthesis of Barmumycin

Dias, Rafael Mafra de P. ; Burtoloso, Antonio C. B. ;

Abstract:

α,β-unsaturated diazoketones have been proven to be interesting multi-functional building blocks in organic chemistry. An interesting reaction, little studied with these building blocks is the Aza-Michael reaction. This reaction consists in an important tool for the formation of C-N bonds and is extremely useful in the synthesis of natural products. In this context, we studied the Michael reaction with α,β- unsaturated diazoketones and its application in the synthesis of barmumycin (a natural product with antitumor activity).

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Palavras-chave: Diazocompounds, Aza-Michael addition, Barmumycin,

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DOI: 10.5151/chempro-15bmos-BMOS2013_2013915202112

Referências bibliográficas
  • [1] 1 Pinho, V. D.; Burtoloso, A. C. B. J. Org. Chem., 2011, 76, 289.
  • [2] 2 Rulev, A. Y. Russ. Chem. Rev. 2011, 80, 197.
Como citar:

Dias, Rafael Mafra de P.; Burtoloso, Antonio C. B.; "α,β-Unsaturated Diazoketones in Aza-Michael Additions - Application in the synthesis of Barmumycin", p. 271 . In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 2, Dezembro.2013. São Paulo: Blucher, 2013.
ISSN 2318-4043, DOI 10.5151/chempro-15bmos-BMOS2013_2013915202112

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