Dezembro 2013 vol. 1 num. 2 - Brazilian Meeting on Organic Synthesis 2013

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An expeditious approach to tetrahydroindolizines from Morita- Baylis-Hillman Adducts

Teodoro, Bruno V. M. ; Correia, José Tiago M. ; Coelho, Fernando ;

Abstract:

Indolizines are important building blocks for synthesis of biomarkers, drugs and alkaloids that posses the indolizidinic core. This type of heteroaromatic skeleton can be prepared using different approaches. Recently Morita-Baylis- Hillman adducts were used as building block for the synthesis of indolizidinic unity. However, applications of these molecules remain almost unexplored. In this communication, we disclosed our preliminary results on a simple strategy to access tetrahydroindolizines and indolizidines by partial or total hydrogenation of indolizines prepared from MBH adducts.

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Palavras-chave: indolizines, Morita-Baylis-Hillman (MBH) Reaction, hydrogenation,

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DOI: 10.5151/chempro-15bmos-BMOS2013_201310100158

Referências bibliográficas
  • [1] 1Gadad, A. K.; Mahajanshetti, C. S.; Nimbalkar, S.; Raichurkar, A. Eur. J. Med. Chem. 2000, 35, 853.
  • [2] 2 Coelho, F.; Almeida, W. P.; Mateus, C. R.; Feltrin, M.; Costa, A. M. Tetrahedron 2001, 57, 6901.
  • [3] 3 Rodrigues Jr., M. T.; Gomes, J. C.; Smith, J.; Coelho, F. Tetrahedron Lett. 2010, 51, 4988.
Como citar:

Teodoro, Bruno V. M.; Correia, José Tiago M.; Coelho, Fernando; "An expeditious approach to tetrahydroindolizines from Morita- Baylis-Hillman Adducts", p. 26 . In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 2, Dezembro.2013. São Paulo: Blucher, 2013.
ISSN 2318-4043, DOI 10.5151/chempro-15bmos-BMOS2013_201310100158

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