Asymmetric enzymatic reduction and Suzuki-Miyaura coupling for the synthesis of odanacatib

Asymmetric enzymatic reduction and Suzuki-Miyaura coupling for the synthesis of odanacatib

Lopes, Raquel de Oliveira; Reichart, Benedikt; Glasnov, Toma; Kappe, C. Oliver; Kroutil, Wolfgang; Miranda, Leandro Soter de M. e; Leal, Ivana Correa R.; Souza, Rodrigo O. M. A. de

Abstract:

The odanacatib (1) (Figure 1) is a specific inhibitor of cathepsin K acting as an antiresorptive agent that preserves bone-formation for the osteoporosis treatment. The clinical trial (phase III) of odanacatib (1) accomplished early due to the potencial efficacy, safety and favorable benefit-risk profile. By considering the important role of odanacatib (1) for the osteoporosis treatment, the aim of this work is to develop new biocatalysts synthetic routes for building blocks of 1 by using microwave and continuous flow as strategy tools for reaction process optimization

The odanacatib (1) (Figure 1) is a specific inhibitor of cathepsin K acting as an antiresorptive agent that preserves bone-formation for the osteoporosis treatment. The clinical trial (phase III) of odanacatib (1) accomplished early due to the potencial efficacy, safety and favorable benefit-risk profile. By considering the important role of odanacatib (1) for the osteoporosis treatment, the aim of this work is to develop new biocatalysts synthetic routes for building blocks of 1 by using microwave and continuous flow as strategy tools for reaction process optimization

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DOI: 10.5151/chempro-15bmos-BMOS2013_201391717510

Referências bibliográficas

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Como citar:

Lopes, Raquel de Oliveira; Reichart, Benedikt; Glasnov, Toma; Kappe, C. Oliver; Kroutil, Wolfgang; Miranda, Leandro Soter de M. e; Leal, Ivana Correa R.; Souza, Rodrigo O. M. A. de; "Asymmetric enzymatic reduction and Suzuki-Miyaura coupling for the synthesis of odanacatib", p-104-104. In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 2, Dezembro.2013. São Paulo: Blucher, 2013.
ISSN 23184043, DOI 10.5151/chempro-15bmos-BMOS2013_201391717510