Dezembro 2013 vol. 1 num. 2 - Brazilian Meeting on Organic Synthesis 2013

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Asymmetric enzymatic reduction and Suzuki-Miyaura coupling for the synthesis of odanacatib

Lopes, Raquel de Oliveira ; Reichart, Benedikt ; Glasnov, Toma ; Kappe, C. Oliver ; Kroutil, Wolfgang ; Miranda, Leandro Soter de M. e ; Leal, Ivana Correa R. ; Souza, Rodrigo O. M. A. de ;

Abstract:

The odanacatib (1) (Figure 1) is a specific inhibitor of cathepsin K acting as an antiresorptive agent that preserves bone-formation for the osteoporosis treatment. The clinical trial (phase III) of odanacatib (1) accomplished early due to the potencial efficacy, safety and favorable benefit-risk profile. By considering the important role of odanacatib (1) for the osteoporosis treatment, the aim of this work is to develop new biocatalysts synthetic routes for building blocks of 1 by using microwave and continuous flow as strategy tools for reaction process optimization

Abstract:

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Palavras-chave: Odanacatib, Biocatalysis, Sukuzi-Miyaura coupling,

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DOI: 10.5151/chempro-15bmos-BMOS2013_201391717510

Referências bibliográficas
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Como citar:

Lopes, Raquel de Oliveira; Reichart, Benedikt; Glasnov, Toma; Kappe, C. Oliver; Kroutil, Wolfgang; Miranda, Leandro Soter de M. e; Leal, Ivana Correa R.; Souza, Rodrigo O. M. A. de; "Asymmetric enzymatic reduction and Suzuki-Miyaura coupling for the synthesis of odanacatib", p. 104 . In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 2, Dezembro.2013. São Paulo: Blucher, 2013.
ISSN 2318-4043, DOI 10.5151/chempro-15bmos-BMOS2013_201391717510

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