Biginelli reaction using lemon juice as catalyst under microwave irradiation

Biginelli reaction using lemon juice as catalyst under microwave irradiation

*, Thalita Corrêa C. de Oliveira; Souza, Andrea Luzia F. de

Abstract:

Actually, multicomponent reaction (MCR) has been seen target of organic synthetic chemists due your specificity in furnish desired products without side reactions. In 1893, Pietro Biginelli published your pioneer research about a MCR that knowed as Biginelli reactiob. This MCR was carried out in one-pot and furnished 5-ethoxycarbonyl-6-methyl-4- phenyl-3,4- dihydropirimidin-2(1H)-one (DHPM) as only product from reaction between benzaldehyde, ethyl acetoacetate and urea under acid catalysis. Biginelli reaction has been developed in several reaction medium, mainly under microwave irradiation. This reaction has been furnished many compounds with pharmacological activity potentials such as, for example, Monastrol, that can anti-cancer activity. Many studies shown that DHPMs has been prepared from Biginelli reaction in presence or free-solvent and different catalysts. In this work was realized a methodology for obtention DHPMs via Biginelli reaction under microwave irradiation, lemon juice was used as catalyst.

Actually, multicomponent reaction (MCR) has been seen target of organic synthetic chemists due your specificity in furnish desired products without side reactions. In 1893, Pietro Biginelli published your pioneer research about a MCR that knowed as Biginelli reactiob. This MCR was carried out in one-pot and furnished 5-ethoxycarbonyl-6-methyl-4- phenyl-3,4- dihydropirimidin-2(1H)-one (DHPM) as only product from reaction between benzaldehyde, ethyl acetoacetate and urea under acid catalysis. Biginelli reaction has been developed in several reaction medium, mainly under microwave irradiation. This reaction has been furnished many compounds with pharmacological activity potentials such as, for example, Monastrol, that can anti-cancer activity. Many studies shown that DHPMs has been prepared from Biginelli reaction in presence or free-solvent and different catalysts. In this work was realized a methodology for obtention DHPMs via Biginelli reaction under microwave irradiation, lemon juice was used as catalyst.

Palavras-chave:

DOI: 10.5151/chempro-15bmos-BMOS2013_20139160752

Referências bibliográficas

• [1] 1 Biginelli, P. Gaz. Chim. Ital. 1893, 23, 360.
• [2] 2 Sandhu, J. S. Arkivoc 2012, (i), 66.

Como citar:

*, Thalita Corrêa C. de Oliveira; Souza, Andrea Luzia F. de; "Biginelli reaction using lemon juice as catalyst under microwave irradiation", p-15-15. In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 2, Dezembro.2013. São Paulo: Blucher, 2013.
ISSN 23184043, DOI 10.5151/chempro-15bmos-BMOS2013_20139160752