Borylation, Silylation, Fluorination and Fluoroalkylation

Borylation, Silylation, Fluorination and Fluoroalkylation

Hartwig, John F.

Abstract:

This lecture will present a combination of methodology and underlying principles addressing the functionalization of C-H bonds of arenes and alkanes with main group reagents and the fluorination and fluoroalkylation of arenes, heteroarenes, and organic halides. The development of reactions that regioselectively convert aromatic and aliphatic C-H bonds to aryl and alkyl borane and silane derivatives will be presented, along with reactions of these main group species to form a series of functionalized products. The development of reactions of aryl and heteroaryl halides that form fluoroarenes and fluoroalkylarenes also will be presented. The relationships between C-B, C-Si, C-F and C-Rf bond-forming processes will be discussed.

This lecture will present a combination of methodology and underlying principles addressing the functionalization of C-H bonds of arenes and alkanes with main group reagents and the fluorination and fluoroalkylation of arenes, heteroarenes, and organic halides. The development of reactions that regioselectively convert aromatic and aliphatic C-H bonds to aryl and alkyl borane and silane derivatives will be presented, along with reactions of these main group species to form a series of functionalized products. The development of reactions of aryl and heteroaryl halides that form fluoroarenes and fluoroalkylarenes also will be presented. The relationships between C-B, C-Si, C-F and C-Rf bond-forming processes will be discussed.

Palavras-chave:

DOI: 10.5151/chempro-15bmos-11-Hartwig_Speech_15th_BMOS-9.27.13

Referências bibliográficas

• [1] 1 Mkhalid, I. A. I.; Barnard, J. H.; Marder, T. B.; Murphy, J. M.; Hartwig, J. F. Chem. Rev. 2010, 110, 890.
• [2] 2 Simmons, E. M.; Hartwig, J. F. Nature 2012, 483, 70.
• [3] 3 Morimoto, H.; Tsubogo, T.; Litvinas, N. D.; Hartwig, J. F. Angew. Chem. Int. Ed. 2011, 50, 3793.

Como citar:

Hartwig, John F.; "Borylation, Silylation, Fluorination and Fluoroalkylation", p-325-325. In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 2, Dezembro.2013. São Paulo: Blucher, 2013.
ISSN 23184043, DOI 10.5151/chempro-15bmos-11-Hartwig_Speech_15th_BMOS-9.27.13