CHELATOR-PEPTIDE CONJUGATE AS PROTECTOR AGAINST IRON-INDUCED TOXICITY

CHELATOR-PEPTIDE CONJUGATE AS PROTECTOR AGAINST IRON-INDUCED TOXICITY

Goswami, D.; Vitorino1, H. A.; Machini, M. T.; Esposito, B. P.

Abstract:

Iron, the most abundant metal in human body, accumulates mostly in liver and brain. Iron overload in the brain has also been correlated to the origin of several neurodegenerative disorders, including Parkinson’s (PD) and Alzheimer’s disease (AD). Aiming to treat iron overload in the brain, we designed, synthesized and tested a conjugate of Penetratin, a cell-penetrating peptide, with Desferrioxamine, a potent iron chelator.

Iron, the most abundant metal in human body, accumulates mostly in liver and brain. Iron overload in the brain has also been correlated to the origin of several neurodegenerative disorders, including Parkinson’s (PD) and Alzheimer’s disease (AD). Aiming to treat iron overload in the brain, we designed, synthesized and tested a conjugate of Penetratin, a cell-penetrating peptide, with Desferrioxamine, a potent iron chelator.

Palavras-chave:

DOI: 10.5151/chempro-15bmos-BMOS2013_201381915460

Referências bibliográficas

• [1] 1 Schroder, N. et. al. J. Alzheimer’s Disease 2013, 34, 797–812.
• [2] 2 Esposito, B. P.; Epsztejn, S. et. al. Anal. Biochem. 2002, 304, 1-18.
• [3] 3 Esposito, B. P.; Breuer, W. et. al. Blood 2003, 102, 2670-2677.

Como citar:

Goswami, D.; Vitorino1, H. A.; Machini, M. T.; Esposito, B. P.; "CHELATOR-PEPTIDE CONJUGATE AS PROTECTOR AGAINST IRON-INDUCED TOXICITY", p-46-46. In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 2, Dezembro.2013. São Paulo: Blucher, 2013.
ISSN 23184043, DOI 10.5151/chempro-15bmos-BMOS2013_201381915460