Dezembro 2013 vol. 1 num. 2 - Brazilian Meeting on Organic Synthesis 2013

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Chemoenzymatic resolution of fluorinated compounds by lipase CALB under microwave irradiation

Ribeiro, Sandra S. ; Guimarães, Tamara F. ; Porto, André L. M. ;

Abstract:

The synthesis of fluorinated organic compounds has shown an important contribution to the development of pharmaceuticals, agrochemicals and materials, especially due to the electron withdrawing influence of the fluorine groups. This study aimed the investigation of the chemoenzymatic resolution of (±)-1-(3-bromophenyl)-2,2,2-trifluoroethanol 1 and (±)-1-(4-bromophenyl)-2,2,2-trifluoroethanol 2, using lipase from Candida antarctica (CALB) under microwave irradiation and orbital shaker.

Abstract:

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Palavras-chave: Biocatalysis, microwave irradiation, enzymes.,

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DOI: 10.5151/chempro-15bmos-BMOS2013_20131014133533

Referências bibliográficas
  • [1] 1Bogár, K.; Backvall, J-E. Tetrahedron Lett. 2007, 48, 547
  • [2] 2Sakai, T.; Miki, Y.; Nakatani, M.; Ema, T. Uneyama, K.; Utaka,
  • [3] M. Tetrahedron Lett. 1998, 39, 523
  • [4] 3Ribeiro, S. S.; Oliveira, J. R. de; Porto, A. L. M.; J. Braz. Chem.
  • [5] Soc. 2012, 23, 139
  • [6] 4Ribeiro, S. S.; Raminelli, C.; Porto, A. L. M. P. J. of Fluorine
  • [7] Chem. 2013, 154, 53.
Como citar:

Ribeiro, Sandra S.; Guimarães, Tamara F.; Porto, André L. M.; "Chemoenzymatic resolution of fluorinated compounds by lipase CALB under microwave irradiation", p. 302 . In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 2, Dezembro.2013. São Paulo: Blucher, 2013.
ISSN 2318-4043, DOI 10.5151/chempro-15bmos-BMOS2013_20131014133533

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