Dezembro 2013 vol. 1 num. 2 - Brazilian Meeting on Organic Synthesis 2013

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Cu-catalyzed Mild C(sp2)-H Functionalization Assisted by Carboxylic Acids En Route to Hydroxylated Arenes

Gallardo-Donaire, Joan ; Martin, Ruben ;

Abstract:

C-H functionalization protocols have emerged as a powerful tool for the synthesis of complex molecules under the premises of atom, redox and step economy. Nevertheless, examples involving CH functionalization/C-O bond formation are scarce in the literature, especially when using weakly coordinating directing groups (DG). In 2011 we described the Pd-catalyzed direct functionalization of C(sp3)-H bonds using carboxylic acids as DG towards the synthesis of 5-membered benzolactones. This work describes a new Cucatalyzed C(sp2)-H acetoxylation en route to valuable hydroxilated arenes.

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Palavras-chave: C-H functionalization, copper, catalysis,

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DOI: 10.5151/chempro-15bmos-BMOS2013_2013618124023

Referências bibliográficas
  • [1] 1 (a) Yamaguchi, J.; Yamaguchi, A. D.; Itami, K. Angew. Chem. Int. Ed.
  • [2] 2012, 51, 8960 (b) Gutekunst, W. R.; Baran, P. S. Chem. Soc. Rev. 2011,
  • [3] 40, 1976.
  • [4] 2 (a) Wencel-Delord, J.; Dröge, T.; Liu, F.; Glorius, F. Chem. Soc. Rev.
  • [5] 2011, 40, 4740 (b) Acc. Chem. Res., 2012, 45, 788.
  • [6] 3 Novák, P.; Correa, A.; Gallardo-Donaire, J.; Martin, R. Angew. Chem. Int.
  • [7] Ed. 2011, 50, 12236.
  • [8] 3 Gallardo-Donaire, J.; Martin, R. J. Am. Chem. Soc. 2013, DOI:
  • [9] 10.1021/ja4047894. While this manuscript was under revision a related Pdcatalyzed
  • [10] protocol has been described: Li, Y.; Ding, Y.-J.; Wang, J.-Y.; Su,
  • [11] Y.-M.; Wang, X.-S. Org. Lett. 2013, doi: 10.1021/ol400877q.
Como citar:

Gallardo-Donaire, Joan; Martin, Ruben; "Cu-catalyzed Mild C(sp2)-H Functionalization Assisted by Carboxylic Acids En Route to Hydroxylated Arenes", p. 144 . In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 2, Dezembro.2013. São Paulo: Blucher, 2013.
ISSN 2318-4043, DOI 10.5151/chempro-15bmos-BMOS2013_2013618124023

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