Efficient multicomponent synthesis of thiazolidinones from 2- aminoethyl(propyl)morpholine

Efficient multicomponent synthesis of thiazolidinones from 2- aminoethyl(propyl)morpholine

Gouvêa, Daniela Pires; Bervaldt, Gabriele dos Anjos; Neves, Adriana Machado das; Martins, Carolina; Cunico, Wilson João

Abstract:

The small heterocyclic moieties with nitrogen, sulfur and oxygen atom has been an extensive interest in medicinal chemistry because considerable biological activities. Thiazolidinone is one of these types of molecules which exhibits important medicinal properties. These activities include antiinflammatory, antioxidant and antimicrobial. In the literature, methods and cleaner methodologies such as microwaves and sonochemistry are described for the synthesis of thiazolidin-4-ones. The ultrasound irradiation has generated beneficial effects in chemical processes, particularly in cases where traditional methods need prolonged reaction times. In continuation of our work , the aim of this paper is synthesis of five-membered heterocyclic thiazolidinones from the cyclocondensation reaction of 2-aminoethyl(propyl)morpholine, arenealdehydes and mercaptoacetic acid by conventional and sonochemistry methodologies.

The small heterocyclic moieties with nitrogen, sulfur and oxygen atom has been an extensive interest in medicinal chemistry because considerable biological activities. Thiazolidinone is one of these types of molecules which exhibits important medicinal properties. These activities include antiinflammatory, antioxidant and antimicrobial. In the literature, methods and cleaner methodologies such as microwaves and sonochemistry are described for the synthesis of thiazolidin-4-ones. The ultrasound irradiation has generated beneficial effects in chemical processes, particularly in cases where traditional methods need prolonged reaction times. In continuation of our work , the aim of this paper is synthesis of five-membered heterocyclic thiazolidinones from the cyclocondensation reaction of 2-aminoethyl(propyl)morpholine, arenealdehydes and mercaptoacetic acid by conventional and sonochemistry methodologies.

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DOI: 10.5151/chempro-15bmos-BMOS2013_2013101143827

Referências bibliográficas

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• [2] 2 Jain, A.K.A.; Vaidya, A.; Ravichandran, V.; Kashaw, S.K.; Agrawal, R.K. Bioorg. Med.Chem., 2012, 20, 3378.
• [3] 3 Neuenfeldt, P.D.; Duval, A.R.; Drawanz, B.B.; Rosales, P.F.; Claudia R.B. Gomes, C.R.RB.; Pereira, C.P.; Cunico, W. Ultrason Sonochem. 2011, 18, 65.
• [4] 4 Gouvêa, D.P; Bareño,V.D.O.; Bosenbecker, J.; Drawanz, B.B.; Neuenfeldt, P.D.; Siqueira, G.; Cunico, W. Ultrason Sonochem. 2012, 19, 1127.

Como citar:

Gouvêa, Daniela Pires; Bervaldt, Gabriele dos Anjos; Neves, Adriana Machado das; Martins, Carolina; Cunico, Wilson João; "Efficient multicomponent synthesis of thiazolidinones from 2- aminoethyl(propyl)morpholine", p-123-123. In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 2, Dezembro.2013. São Paulo: Blucher, 2013.
ISSN 23184043, DOI 10.5151/chempro-15bmos-BMOS2013_2013101143827