Dezembro 2013 vol. 1 num. 2 - Brazilian Meeting on Organic Synthesis 2013

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Facile one-pot synthesis of novel 1,2,4-Triazin-5-one from intramolecular cyclization

Rosa, Fernanda A. ; Gonçalves, Davana S. ; Silva, Michael J. V. da ; Tozatti, Camila S. S. ; Gauze, Gisele F. ;

Abstract:

The triazinones are integral part of class bioactive in the heterocyclic compounds. In particular the 1,2,4- Triazin-5-ones are very important in class of these compounds and have attracted particular attention in the pharmaceutical and agrochemical industries, as have exhibited potential activity antitumor, anticancer, antiulcer, and anti-inflammatory effects, activity as herbicides, desiccants, defoliants, plant growth regulators and insecticides. Numerous methods for the synthesis of these compounds have been published, among them, there are condensation reactions of hydrazide and hydrazones with primary amines or acetals derivatives and cyclization obtained by treatment thermal and in the presence of acid. In this work, we attempted to synthesis 1,2,4- triazin- 5-ones through a new method using condensations in the 2-hydrazonopropanehydrazide (1) with N,N-Dimethylformamide dimethyl acetal (DMFDMA) and intramolecular cyclization by acid catalyzed.

Abstract:

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Palavras-chave: intramolecular cyclization, heterocycles, triazinones,

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DOI: 10.5151/chempro-15bmos-BMOS2013_201391017547

Referências bibliográficas
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Como citar:

Rosa, Fernanda A.; Gonçalves, Davana S.; Silva, Michael J. V. da; Tozatti, Camila S. S.; Gauze, Gisele F.; "Facile one-pot synthesis of novel 1,2,4-Triazin-5-one from intramolecular cyclization", p. 67 . In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 2, Dezembro.2013. São Paulo: Blucher, 2013.
ISSN 2318-4043, DOI 10.5151/chempro-15bmos-BMOS2013_201391017547

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