Dezembro 2013 vol. 1 num. 2 - Brazilian Meeting on Organic Synthesis 2013

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Microwave-assisted synthesis and antifungal activity of calix[4]aldimines

Silva, Cleiton M. da ; Magalhães, Thais F.F. ; Silva, Danielle L. da ; Alves, Rosemeire B. ; Resende-Stoianoff, Maria A. de ; Fátima, Ângelo de ;

Abstract:

Calixarenes are macrocyclic compounds formed of phenolic units linked by methylene bridges in ortho positions. In last decades these compounds have received increasing attention due to its technological and biological applications, particularly as platforms for the development of new drugs. Aldimines are organic substances known to exhibit a broad range of biological properties that includes antifungal, antibacterial, antimalarial, anti-inflammatory and antiviral activities. Here we report the microwave-assisted synthesis of six calix[4]aldimines and their respective monomeric units. The antifungal activities of such compounds against six strains of Candida species are also described.

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Palavras-chave: calixarene, aldimine, antifungal activity.,

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DOI: 10.5151/chempro-15bmos-BMOS2013_2013820144926

Referências bibliográficas
  • [1] 1 de Fátima, A.; Fernandes, S. A.; Sabino, A. A. Curr. Drug. Discov. Tech.
  • [2] 2009, 6, 151.
  • [3] 2 da Silva, C. M.; da Silva, D. L.; Modolo, L. V.; Alves, R. B.; Martins, C. V.
  • [4] B.; de Resende, M. A.; de Fátima, A. J. Adv. Res. 2011, 2, 1.
  • [5] 3 Clinical and Laboratory Standards Institute. Reference Method for Broth
  • [6] Dilution Antifungal Susceptibility Testing of Yeasts. Approved standard,
  • [7] 2nd ed. NCCLS document M27-A2. Villanova: Clinical and Laboratory
  • [8] Standards Institute. 2002.
Como citar:

Silva, Cleiton M. da; Magalhães, Thais F.F.; Silva, Danielle L. da; Alves, Rosemeire B.; Resende-Stoianoff, Maria A. de; Fátima, Ângelo de; "Microwave-assisted synthesis and antifungal activity of calix[4]aldimines", p. 184 . In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 2, Dezembro.2013. São Paulo: Blucher, 2013.
ISSN 2318-4043, DOI 10.5151/chempro-15bmos-BMOS2013_2013820144926

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