Dezembro 2013 vol. 1 num. 2 - Brazilian Meeting on Organic Synthesis 2013

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Microwave irradiation and DMC: a potent combination for the synthesis of 2-arylamino-3-tritylsulfanyl-propionic ethyl ester

Santo, Stephanie Amarillis E. ; Jr., Luiz S. Longo ; Reis, Adriana Karla C. Amorim ;

Abstract:

HIV-1 protease (HIV-1-PR) has a critical role in the life cycle of HIV-1. In order to reduce the overall viral replication, an attractive alternative is to improve the pharmacological properties, pharmacokinetic and safety profiles of the potential therapeutic anti-proteases drugs (PAs), such as Nelfinavir (II) (antiretroviral drug). This work reports our preliminary results obtained in the synthesis of N-(1-hydroxy-3-mercaptopropan-2-ylarylamides (I) via the coupling reaction of N-(1-hydroxy-3- mercaptopropan-2-yl)aryl-amides with benzoic acid derivatives using classical as well green solvents.

Abstract:

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Palavras-chave: HIV-Protease, Microwave, Coupling Reactions,

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DOI: 10.5151/chempro-15bmos-BMOS2013_201396161153

Referências bibliográficas
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Como citar:

Santo, Stephanie Amarillis E.; Jr., Luiz S. Longo; Reis, Adriana Karla C. Amorim; "Microwave irradiation and DMC: a potent combination for the synthesis of 2-arylamino-3-tritylsulfanyl-propionic ethyl ester", p. 115 . In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 2, Dezembro.2013. São Paulo: Blucher, 2013.
ISSN 2318-4043, DOI 10.5151/chempro-15bmos-BMOS2013_201396161153

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