Dezembro 2013 vol. 1 num. 2 - Brazilian Meeting on Organic Synthesis 2013

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New modular structures constructed by click chemistry

Valdomir, Guillermo ; Padrón, José M. ; Padrón, Juan I. ; Martín, Víctor S. ; Davyt, Danilo ;

Abstract:

Inspired by diferent natural compounds withcytotoxic activity, we synthesised new modularcompounds by Click Chemistry, using two kinds ofbuilding blocks which can be easily coupled. TheCu(I) catalyzed version of the Huisgen reaction, wasthe tool selected for the coupling of the buildingblocks. These compounds have been tested todetermine their antiproliferative activity against fivehuman solid tumor cell lines.

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Palavras-chave: Click Chemistry, Huisgen reaction, Antiproliferative activity.,

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DOI: 10.5151/chempro-15bmos-BMOS2013_201381919619

Referências bibliográficas
  • [1] 1 Kolb, H. C.; Finn, M. G.; Sharpless, K. B. Angew. Chem. Int. Ed. 2001, 40, 2004.
  • [2] 2 Fuchs, P. L.; Corey, E. J. Tetrahedron Lett. 1972, 13, 3769.
  • [3] 3 Phillips, A. J.; Uto, Y.; Wipf, P.; Reno, M. J.; Williams, D. R. Org. Lett. 2000, 2, 1165.
Como citar:

Valdomir, Guillermo; Padrón, José M.; Padrón, Juan I.; Martín, Víctor S.; Davyt, Danilo; "New modular structures constructed by click chemistry", p. 48 . In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 2, Dezembro.2013. São Paulo: Blucher, 2013.
ISSN 2318-4043, DOI 10.5151/chempro-15bmos-BMOS2013_201381919619

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