Dezembro 2013 vol. 1 num. 2 - Brazilian Meeting on Organic Synthesis 2013

Abstract - Open Access.

Idioma principal

Preparation and preliminiar evaluation of new organometallic bases from cis-2,6-dimethylpiperidine

Pina, Evelyn Mirella Lopes ; Pereira, Natália de Araujo ; Soldi, Rafael Augusto ; Clososki, Giuliano Cesar ;

Abstract:

Recently, magnesiate and zincate reagents have proven their synthetic importance for the functionalization of arenes. In addition, mixed Li/Mg and Li/Zn amides prepared from 2,2,6,6- tetramethylpyperidine (TMPH) are highly soluble and active bases that allow smoothly metalatation of various aromatic and heteroarenes with an excellent fuctional group tolerance. In this work, we have been investigating the preparation and the reactivity of mixed metal bases from cis-2,6-dimethylpiperidine (DMPH) as alternative for TMP-metal bases.

Abstract:

Download (PDF)

Palavras-chave: cis-2,6-dimethylpiperidine, heterocyclic substrates, Negishi cross-coupling,

Palavras-chave:

DOI: 10.5151/chempro-15bmos-BMOS2013_2013915232924

Referências bibliográficas
  • [1] 1Kondo, Y.; Shilai, H.; Uchiyama, M.; Sakamoto, T. J. Am.
  • [2] Chem. Soc. 1999, 121, 3539.
  • [3] 2 Bresser, T.; Mosrin, M.; Monzon, G.; Knochel, P. J. Org. Chem.
  • [4] 2010, 75, 4686.
Como citar:

Pina, Evelyn Mirella Lopes; Pereira, Natália de Araujo; Soldi, Rafael Augusto; Clososki, Giuliano Cesar; "Preparation and preliminiar evaluation of new organometallic bases from cis-2,6-dimethylpiperidine", p. 280 . In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 2, Dezembro.2013. São Paulo: Blucher, 2013.
ISSN 2318-4043, DOI 10.5151/chempro-15bmos-BMOS2013_2013915232924

últimos 30 dias | último ano | desde a publicação


downloads


visualizações


indexações