SCNS. 09. Pre-clinical evidence of antimaniac action by angiotensin II receptor blocker.

SCNS. 09. Pre-clinical evidence of antimaniac action by angiotensin II receptor blocker.

GOMES, J.A.S.; TOMAZ, V.S.; SOUZA, G.C.; CAVALCANTE, L.M.; MACÊDO, D.

Abstract:

The Bipolar Disorder (BD), a chronic psychiatric disorder, is highly prevalent and associated with functional disability and with excessive costs to the health system. The renin-angiotensin system (RAS) has been studied concerning neurological diseases, and the role of angiotensin II is being currently recognized as an important factor in anxiety and mood disorders. The deregulation of SRA brain is associated with the formation of reactive oxygen species, activation of pro-inflammatory pathways, reduced neuroplasticity and mitochondrial dysfunction. It is noteworthy that all these events are related to the pathophysiology of BD.

The Bipolar Disorder (BD), a chronic psychiatric disorder, is highly prevalent and associated with functional disability and with excessive costs to the health system. The renin-angiotensin system (RAS) has been studied concerning neurological diseases, and the role of angiotensin II is being currently recognized as an important factor in anxiety and mood disorders. The deregulation of SRA brain is associated with the formation of reactive oxygen species, activation of pro-inflammatory pathways, reduced neuroplasticity and mitochondrial dysfunction. It is noteworthy that all these events are related to the pathophysiology of BD.

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DOI: 10.5151/isnm-sine14

Como citar:

GOMES, J.A.S.; TOMAZ, V.S.; SOUZA, G.C.; CAVALCANTE, L.M.; MACÊDO, D.; "SCNS. 09. Pre-clinical evidence of antimaniac action by angiotensin II receptor blocker.", p-19-19. In: In I International Symposium in Neuroscience Meeting, 2013 [Blucher Neuroscience Proceedings n.1 v.1]. São Paulo: Blucher, 2014.
ISSN 2357772x, DOI 10.5151/isnm-sine14